HER2 ātras internalizācijas un novirzītas cilvēku tirdzniecības molekulārais

HER2 ātras internalizācijas un novirzītas cilvēku tirdzniecības molekulārais mehānisms, ko izraisa anti-HER2 biparatopiskais antiviela

  • HER2 (cilvēka epidermas attīstības problēmas 2. receptora), ErbB2 receptoru tirozīna kināzes, pastiprināšanās un pārmērīga ekspresija ir saistīta ar lielāko daļu cilvēku vēža un metastāžu. Ir ziņots, ka bispecifiska četrvērtīga anti-HER2 antiviela (anti-HER2-Bs), kas koncentrējas uz diviem HER2 nepilējošiem epitopiem IV zonā (trastuzumabs) un II zonā (39S), izraisa ātru HER2 internalizāciju un videi draudzīgu degradāciju. receptori. 
  • Šajā pētījumā mēs izpētījām šīs antivielu izraisītās ātrās HER2 internalizācijas un intracelulārās tirdzniecības molekulāro mehānismu. Izmantojot kvantitatīvo fluorescējošo attēlveidošanu, mēs pretstatām anti-HER2-B un tā vecāku roku antivielu internalizācijas kinētikai atsevišķi vai maisījumos un daudzos internalizāciju veicinošos apstākļos. Rezultāti parādīja, ka ātrai anti-HER2-B internalizācijai izšķiroša nozīme bija vienlaicīgai katra epitopa iesaistei.
  • Anti-HER2-B un vecāku roku antivielu mobilā uzņemšana notika no klatrīna atkarīgas endocitozes veidā; tomēr antivielas šūnās satur pilnīgi atšķirīgus cilvēku tirdzniecības ceļus. Trastuzumabs 2 stundu laikā disociējās no HER2, ļaujot receptoriem atkārtoti pārstrādāt, savukārt anti-HER2-B palika saistīti ar receptoru visā endocītiskajā ceļā, pārdodot receptoru ubikvitināciju, tirdzniecību ar lizosomām un videi draudzīgu noārdīšanos.
  • Atbilstoši HER2 novirzīšanai uz degradāciju, anti-HER2-B ievērojami samazināja HER2 izdalīšanos un mainīja tā eksosomālo eksportu. Kopā šie rezultāti ļauj labāk izprast anti-Her2-B kustības mehānismu un var sniegt informāciju par racionālu anti-HER2 terapijas dizainu papildus dažādām bispecifiskām molekulām.

Cilvēkiem ar receptoru saistošās domēna specifiskās neitralizējošās monoklonālās antivielas pretstatā SARS-CoV un SARS-CoV-2

Ārkārtējā akūtā elpošanas sindroma (SARS) un 2019. gada koronavīrusa slimības (COVID-19) uzliesmojumi, ko izraisīja attiecīgi SARS-CoV un SARS-CoV-2, ir ārkārtīgi apdraudējuši pasaules sabiedrības labklājību un ekonomisko sistēmu. Šo vīrusu slimību terapija un profilakse ir cilvēka neitralizējošo monoklonālo antivielu (NMAbs) analīze un augšana.

Zinātnieki ir skrīnējuši neitralizējošās antivielas, kā antigēnu izmantojot vīrusa receptoru saistošo zonu (RBD), norādot, ka RBD ir iekļauti vairāki konformācijas neitralizējoši epitopi, kas ir galvenie strukturālie domēni neitralizējošo antivielu un T-šūnu imūnreakciju inducēšanai. Šajā novērtējumā ir apkopota RBD un RBD specifisko NMAb konstrukcija un veiktspēja, pretstatā SARS-CoV un SARS-CoV-2 pašlaik zem izaugsmes.

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Description: A Mouse monoclonal antibody against Pig Interleukin 8 (IL8). This antibody is labeled with APC.

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Description: A Mouse monoclonal antibody against Pig Interleukin 8 (IL8). This antibody is labeled with Cy3.

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Description: A Mouse monoclonal antibody against Pig Interleukin 8 (IL8). This antibody is labeled with HRP.

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Description: A Mouse monoclonal antibody against Pig Interleukin 8 (IL8). This antibody is labeled with APC.

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Description: A Mouse monoclonal antibody against Pig Interleukin 8 (IL8). This antibody is labeled with Cy3.

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Description: A Mouse monoclonal antibody against Pig Interleukin 8 (IL8). This antibody is labeled with HRP.

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Description: A Mouse monoclonal antibody against Pig Interleukin 8 (IL8). This antibody is labeled with APC.

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Description: A Mouse monoclonal antibody against Pig Interleukin 8 (IL8). This antibody is labeled with Cy3.

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Description: A Mouse monoclonal antibody against Pig Interleukin 8 (IL8). This antibody is labeled with HRP.

Interleukin 8 (IL8) Monoclonal Antibody (Horse), PE

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Description: A Mouse monoclonal antibody against Pig Interleukin 8 (IL8). This antibody is labeled with FITC.

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Description: A Mouse monoclonal antibody against Pig Interleukin 8 (IL8). This antibody is labeled with FITC.

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Description: A Mouse monoclonal antibody against Pig Interleukin 8 (IL8). This antibody is labeled with FITC.

Interleukin 8 (IL8) Monoclonal Antibody (Human, Dog)

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Description: A Mouse monoclonal antibody against Human, Dog Interleukin 8 (IL8)

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Description: A Mouse monoclonal antibody against Horse Interleukin 8 (IL8). This antibody is labeled with APC.

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Description: A Mouse monoclonal antibody against Horse Interleukin 8 (IL8). This antibody is labeled with Cy3.

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Description: A Mouse monoclonal antibody against Horse Interleukin 8 (IL8). This antibody is labeled with HRP.

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Description: A Mouse monoclonal antibody against Human Interleukin 8 (IL8). This antibody is labeled with Cy3.

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Description: A Mouse monoclonal antibody against Human Interleukin 8 (IL8). This antibody is labeled with HRP.

Interleukin 8 (IL8) Monoclonal Antibody (Human), APC

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Description: A Mouse monoclonal antibody against Human Interleukin 8 (IL8). This antibody is labeled with APC.

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Description: A Mouse monoclonal antibody against Human Interleukin 8 (IL8). This antibody is labeled with Cy3.

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Interleukin 8 (IL8) Monoclonal Antibody (Rabbit), PE

4-MAA080Rb22-PE
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Description: A Mouse monoclonal antibody against Rabbit Interleukin 8 (IL8). This antibody is labeled with PE.

Interleukin 8 (IL8) Monoclonal Antibody (Horse), FITC

4-MAA080Eq21-FITC
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Description: A Mouse monoclonal antibody against Horse Interleukin 8 (IL8). This antibody is labeled with FITC.

Interleukin 8 (IL8) Monoclonal Antibody (Chicken), PE

4-MAA080Ga22-PE
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Description: A Mouse monoclonal antibody against Chicken Interleukin 8 (IL8). This antibody is labeled with PE.

Interleukin 8 (IL8) Monoclonal Antibody (Guinea pig)

4-MAA080Gu21
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Description: A Mouse monoclonal antibody against Guinea pig Interleukin 8 (IL8)

Interleukin 8 (IL8) Monoclonal Antibody (Guinea pig)

4-MAA080Gu24
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Description: A Mouse monoclonal antibody against Guinea pig Interleukin 8 (IL8)

Interleukin 8 (IL8) Monoclonal Antibody (Human), FITC

4-MAA080Hu22-FITC
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Description: A Mouse monoclonal antibody against Human Interleukin 8 (IL8). This antibody is labeled with FITC.

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4-MAA080Hu24-FITC
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Description: A Mouse monoclonal antibody against Human Interleukin 8 (IL8). This antibody is labeled with FITC.

Interleukin 8 (IL8) Monoclonal Antibody (Rabbit), APC

4-MAA080Rb22-APC
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Description: A Mouse monoclonal antibody against Rabbit Interleukin 8 (IL8). This antibody is labeled with APC.

Interleukin 8 (IL8) Monoclonal Antibody (Rabbit), Cy3

4-MAA080Rb22-Cy3
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Description: A Mouse monoclonal antibody against Rabbit Interleukin 8 (IL8). This antibody is labeled with Cy3.

Interleukin 8 (IL8) Monoclonal Antibody (Rabbit), HRP

4-MAA080Rb22-HRP
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Description: A Mouse monoclonal antibody against Rabbit Interleukin 8 (IL8). This antibody is labeled with HRP.

Interleukin 8 (IL8) Monoclonal Antibody (Chicken), APC

4-MAA080Ga22-APC
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Description: A Mouse monoclonal antibody against Chicken Interleukin 8 (IL8). This antibody is labeled with APC.

Interleukin 8 (IL8) Monoclonal Antibody (Chicken), Cy3

4-MAA080Ga22-Cy3
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Description: A Mouse monoclonal antibody against Chicken Interleukin 8 (IL8). This antibody is labeled with Cy3.

Interleukin 8 (IL8) Monoclonal Antibody (Chicken), HRP

4-MAA080Ga22-HRP
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Description: A Mouse monoclonal antibody against Chicken Interleukin 8 (IL8). This antibody is labeled with HRP.

Interleukin 8 (IL8) Monoclonal Antibody (Rabbit), FITC

4-MAA080Rb22-FITC
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Description: A Mouse monoclonal antibody against Rabbit Interleukin 8 (IL8). This antibody is labeled with FITC.

Interleukin 8 (IL8) Monoclonal Antibody (Chicken), FITC

4-MAA080Ga22-FITC
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Description: A Mouse monoclonal antibody against Chicken Interleukin 8 (IL8). This antibody is labeled with FITC.

Interleukin 8 (IL8) Monoclonal Antibody (Rhesus monkey)

4-MAA080Si21
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Description: A Mouse monoclonal antibody against Rhesus monkey Interleukin 8 (IL8)

Interleukin 8 (IL8) Monoclonal Antibody (Rhesus monkey)

4-MAA080Si22
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Description: A Mouse monoclonal antibody against Rhesus monkey Interleukin 8 (IL8)

Interleukin 8 (IL8) Monoclonal Antibody (Pig), Biotinylated

4-MAA080Po22-Biotin
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Description: A Mouse monoclonal antibody against Pig Interleukin 8 (IL8). This antibody is labeled with Biotin.

Interleukin 8 (IL8) Monoclonal Antibody (Pig), Biotinylated

4-MAA080Po24-Biotin
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Description: A Mouse monoclonal antibody against Pig Interleukin 8 (IL8). This antibody is labeled with Biotin.

Interleukin 8 (IL8) Monoclonal Antibody (Pig), Biotinylated

4-MAA080Po26-Biotin
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Description: A Mouse monoclonal antibody against Pig Interleukin 8 (IL8). This antibody is labeled with Biotin.

Interleukin 8 (IL8) Monoclonal Antibody (Human, Dog), PE

4-MAA080Ca22-PE
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Description: A Mouse monoclonal antibody against Human, Dog Interleukin 8 (IL8). This antibody is labeled with PE.

PE Linked Monoclonal Antibody to Interleukin 8 (IL8)

MBS2128185-INQUIRE INQUIRE Ask for price

PE Linked Monoclonal Antibody to Interleukin 8 (IL8)

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Interleukin 8 (IL8) Monoclonal Antibody (Human, Dog), APC

4-MAA080Ca22-APC
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Description: A Mouse monoclonal antibody against Human, Dog Interleukin 8 (IL8). This antibody is labeled with APC.

Interleukin 8 (IL8) Monoclonal Antibody (Human, Dog), Cy3

4-MAA080Ca22-Cy3
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Description: A Mouse monoclonal antibody against Human, Dog Interleukin 8 (IL8). This antibody is labeled with Cy3.

Interleukin 8 (IL8) Monoclonal Antibody (Human, Dog), HRP

4-MAA080Ca22-HRP
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Description: A Mouse monoclonal antibody against Human, Dog Interleukin 8 (IL8). This antibody is labeled with HRP.

Interleukin 8 (IL8) Monoclonal Antibody (Guinea pig), PE

4-MAA080Gu21-PE
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Description: A Mouse monoclonal antibody against Guinea pig Interleukin 8 (IL8). This antibody is labeled with PE.

Interleukin 8 (IL8) Monoclonal Antibody (Guinea pig), PE

4-MAA080Gu24-PE
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Description: A Mouse monoclonal antibody against Guinea pig Interleukin 8 (IL8). This antibody is labeled with PE.

Interleukin 8 (IL8) Monoclonal Antibody (Pig), APC-Cy7

4-MAA080Po22-APC-Cy7
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Description: A Mouse monoclonal antibody against Pig Interleukin 8 (IL8). This antibody is labeled with APC-Cy7.

Interleukin 8 (IL8) Monoclonal Antibody (Pig), APC-Cy7

4-MAA080Po24-APC-Cy7
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Description: A Mouse monoclonal antibody against Pig Interleukin 8 (IL8). This antibody is labeled with APC-Cy7.

Interleukin 8 (IL8) Monoclonal Antibody (Pig), APC-Cy7

4-MAA080Po26-APC-Cy7
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Description: A Mouse monoclonal antibody against Pig Interleukin 8 (IL8). This antibody is labeled with APC-Cy7.

APC Linked Monoclonal Antibody to Interleukin 8 (IL8)

MBS2128186-INQUIRE INQUIRE Ask for price

Cy3 Linked Monoclonal Antibody to Interleukin 8 (IL8)

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HRP Linked Monoclonal Antibody to Interleukin 8 (IL8)

MBS2128190-INQUIRE INQUIRE Ask for price

APC Linked Monoclonal Antibody to Interleukin 8 (IL8)

MBS2128193-INQUIRE INQUIRE Ask for price

Cy3 Linked Monoclonal Antibody to Interleukin 8 (IL8)

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HRP Linked Monoclonal Antibody to Interleukin 8 (IL8)

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Interleukin 8 (IL8) Monoclonal Antibody (Horse), Biotinylated

4-MAA080Eq21-Biotin
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Description: A Mouse monoclonal antibody against Horse Interleukin 8 (IL8). This antibody is labeled with Biotin.

Interleukin 8 (IL8) Monoclonal Antibody (Human), Biotinylated

4-MAA080Hu22-Biotin
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Description: A Mouse monoclonal antibody against Human Interleukin 8 (IL8). This antibody is labeled with Biotin.

Interleukin 8 (IL8) Monoclonal Antibody (Human), Biotinylated

4-MAA080Hu24-Biotin
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Description: A Mouse monoclonal antibody against Human Interleukin 8 (IL8). This antibody is labeled with Biotin.

PE-Linked Monoclonal Antibody to Interleukin 8 (IL8)

LAA080Rb42 270 ul
EUR 507

Interleukin 8 (IL8) Monoclonal Antibody (Human, Dog), FITC

4-MAA080Ca22-FITC
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Description: A Mouse monoclonal antibody against Human, Dog Interleukin 8 (IL8). This antibody is labeled with FITC.

Interleukin 8 (IL8) Monoclonal Antibody (Guinea pig), APC

4-MAA080Gu21-APC
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Description: A Mouse monoclonal antibody against Guinea pig Interleukin 8 (IL8). This antibody is labeled with APC.

Interleukin 8 (IL8) Monoclonal Antibody (Guinea pig), Cy3

4-MAA080Gu21-Cy3
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Description: A Mouse monoclonal antibody against Guinea pig Interleukin 8 (IL8). This antibody is labeled with Cy3.

Interleukin 8 (IL8) Monoclonal Antibody (Guinea pig), HRP

4-MAA080Gu21-HRP
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Description: A Mouse monoclonal antibody against Guinea pig Interleukin 8 (IL8). This antibody is labeled with HRP.

Interleukin 8 (IL8) Monoclonal Antibody (Guinea pig), APC

4-MAA080Gu24-APC
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Description: A Mouse monoclonal antibody against Guinea pig Interleukin 8 (IL8). This antibody is labeled with APC.

Interleukin 8 (IL8) Monoclonal Antibody (Guinea pig), Cy3

4-MAA080Gu24-Cy3
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Description: A Mouse monoclonal antibody against Guinea pig Interleukin 8 (IL8). This antibody is labeled with Cy3.

Interleukin 8 (IL8) Monoclonal Antibody (Guinea pig), HRP

4-MAA080Gu24-HRP
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Description: A Mouse monoclonal antibody against Guinea pig Interleukin 8 (IL8). This antibody is labeled with HRP.

PE-Linked Monoclonal Antibody to Interleukin 8 (IL8)

MBS2037149-INQUIRE INQUIRE Ask for price

PE-Linked Monoclonal Antibody to Interleukin 8 (IL8)

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PE-Linked Monoclonal Antibody to Interleukin 8 (IL8)

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PE-Linked Monoclonal Antibody to Interleukin 8 (IL8)

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PE-Linked Monoclonal Antibody to Interleukin 8 (IL8)

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PE-Linked Monoclonal Antibody to Interleukin 8 (IL8)

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PE-Linked Monoclonal Antibody to Interleukin 8 (IL8)

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PE-Linked Monoclonal Antibody to Interleukin 8 (IL8)

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PE-Linked Monoclonal Antibody to Interleukin 8 (IL8)

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PE-Linked Monoclonal Antibody to Interleukin 8 (IL8)

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PE-Linked Monoclonal Antibody to Interleukin 8 (IL8)

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PE-Linked Monoclonal Antibody to Interleukin 8 (IL8)

MBS2118048-INQUIRE INQUIRE Ask for price

PE-Linked Monoclonal Antibody to Interleukin 8 (IL8)

MBS2106147-INQUIRE INQUIRE Ask for price

APC_Cy7 Linked Monoclonal Antibody to Interleukin 8 (IL8)

MBS2128184-INQUIRE INQUIRE Ask for price

FITC Linked Monoclonal Antibody to Interleukin 8 (IL8)

MBS2128189-INQUIRE INQUIRE Ask for price

APC_Cy7 Linked Monoclonal Antibody to Interleukin 8 (IL8)

MBS2128191-INQUIRE INQUIRE Ask for price

FITC Linked Monoclonal Antibody to Interleukin 8 (IL8)

MBS2128196-INQUIRE INQUIRE Ask for price

Interleukin 8 (IL8) Monoclonal Antibody (Rabbit), Biotinylated

4-MAA080Rb22-Biotin
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Description: A Mouse monoclonal antibody against Rabbit Interleukin 8 (IL8). This antibody is labeled with Biotin.

MET un RON receptoru tirozīna kināzes kolorektālajā adenokarcinomā: molekulāras iespējas kā zāļu mērķi un antivielu un zāļu konjugāti ārstēšanai

Augstākā kolorektālā adenokarcinoma (CRAC), ko raksturo atšķirīgs histopatoloģisks izskats, tālu orgānu metastāzes, iegūta ķīmijrezistence un audzēja ģenētiskais stublājs, ir daudz neviendabīgu vēžu ar atšķirīgiem ģenētiskiem parakstiem un ļaundabīgiem fenotipiem. CRAC terapija onkologiem ir biedējoša darbība.

Šobrīd cīņā pret šo letālo slimību ir izmantotas daudzas metodes kopā ar molekulāro koncentrēšanos uz terapeitisko monoklonālo antivielu, mazmolekulāro kināzes inhibitoru un imūnregulācijas kontrolpunkta līdzekli. Tomēr šīs terapeitiskās metodes un pieejas gūst tikai ierobežotus panākumus. Tādējādi farmaceitiski vēlas atrast jaunus mērķus un izstrādāt jaunus CRAC līdzekļa terapijas līdzekļus. MET un RON receptoru tirozīna kināzes ir iesaistītas CRAC patoģenēzē.

Zinātniskie pētījumi ir atklājuši, ka novirzīta MET un / vai RON ekspresija un signalizācija ir būtiska, regulējot CRAC attīstību un ļaundabīgos fenotipus. Paaugstinātai MET un / vai RON izteiksmei ir arī CRAC attīstības un skartās personas izdzīvošanas prognozes vērtība.

Šīs iespējas piedāvā loģisko pamatu koncentrēties uz TER un RON zinātniskai CRAC iejaukšanai. Pašlaik, izmantojot mazmolekulārās kināzes inhibitorus, koncentrējoties uz MET CRAC terapijai, ir panākts būtisks progress, saņemot vairākus apstiprinājumus zinātniskai lietošanai.

Neskatoties uz to, uz antivielām balstītie bioterapeitiskie līdzekļi, lai arī zinātniski pētījumi veikti vairāk nekā astoņus gadus, ir guvuši nelielu progresu vai nav devuši nekādu progresu. Šajā novērtējumā mēs koncentrējamies uz MET un / vai RON nozīmi CRAC audzēja veidošanā un anti-MET, anti-RON un MET un RON-dual augšanu, koncentrējoties uz antivielu un zāļu konjugātiem zinātniskai lietderībai. Katra preklīniskā un zinātniskā pētījuma secinājumi agrāk vai vēlāk atklāj šī jaunā veida bioterapeitisko līdzekļu potenciālu CRAC ārstēšanai.

Seruma anti-Neu5Gc antivielu afinitātes attīrīšana atklāja paaugstinātu diapazonu un neobjektīvus masīvu repertuāra modeļus cilvēkiem, kuriem palielinājās Neu5Gc diapazons, bez antivielu afinitātes palielināšanās. Turklāt augsta gaļas svara samazināšanas plānā antivielu daudzveidības modeļi uz glikāna mikroelementiem mainījās ar Neu5Gcα3 saistīto glikānu virzienā, paaugstinot α3 / α6-glikānu attiecību.

Secinājumi: Mēs atklājām pārredzamu hipersaiti starp grādiem un seruma anti-Neu5Gc IgG un Neu5Gc patēriņu no rozā gaļas un piena produktiem. Šīs precīzās racionālās metodikas ļāva izstrādāt Gcemicindeksu, lai vienkāršotu Neu5Gc novērtēšanu ēdienreizēs, kas, bez šaubām, būtu pielāgots uztura ieteikumiem, lai samazinātu lielāko daļu vēža risku.

Antivielu reakcija uz suņu parvovīrusa vakcināciju suņiem ar hiperadrenokortikismu, kas tiek ārstēta ar Trilostane

  • Nav zināms, kā suņi ar hiperadrenokortikismu (HAC) reaģē uz vakcināciju. Šajā pētījumā tika izmērītas antivielas pretstatā suņu parvovīrusam (CPV) suņiem ar HAC, kas ar trilostānu apstrādāts agrāk un pēc CPV vakcinācijas, un atšķirībā no imūnās atbildes reakcijas uz veselīgu suņu reakciju. 
  • Vienpadsmit ilkņi ar HAC un pilnvērtīgi vecumam atbilstoši suņi (n = 31) ieguva modificētu dzīvo CPV vakcīnu. Antivielas ir izlemtas 0., 7. un 28. dienā ar hemaglutinācijas inhibīciju. Lai saskaņotu suņu imūnreakciju ar HAC un pilnvērtīgiem ilkņiem, tika izmantots vienveidīgais novērtējums.
  • Pirmsvakcinācijas antivielas (≥10) ir atklātas 100% suņu ar HAC (11/11; 95% TI: 70,0-100) un 93,5% pilnvērtīgu suņu (29/31; 95% TI: 78,3- 99.2). Suņiem ar HAC netika novērota ≥Four reizes lielāka antivielu titra palielināšanās, turpretī 22,6% pilnvērtīgu ilkņu gadījumā ≥Four reizes titra palielināšanās tika novērota (7/31; 95% TI: 11,1-40,1).
  • Maigi ar vakcīnu saistīti antagonistiski gadījumi (VAAE) ir konstatēti 54,5% suņu ar HAC (6/11; 95% TI: 28,0-78,8) un 29,0% pilnvērtīgu ilkņu (9/31; 95% TI: 15,9) -46,8). Nebija būtiskas atšķirības pirmsvakcinācijas antivielu klātbūtnē (p = 1.000), atbildes reakcija uz vakcināciju (p = 0.161), kā arī VAAE izplatības ziņā (p = 0.158). Imūnsistēmas suņu darbība ar HAC, kas apstrādāta ar trilostānu, šķiet līdzīga veselīgu ilkņu darbībai.

Linkeru izstrāde un validācija vietņu specifiskai antivielu-narkotiku konjugātu sagatavošanai, kas satur vairākas zāļu kopijas vienā cisteīna konjugācijas vietnē

Pirmās paaudzes cisteīna bāzes specifisko antivielu un zāļu konjugāti (ADC) ir ierobežoti līdz 1 narkotikai uz vienu cisteīnu. Neskatoties uz to, noteiktiem mērķiem nepieciešama pārmērīga zāļu un antivielu attiecība (DAR), kas atbilst zemas jaudas kravām. Palielinātu zāļu slodzi var panākt, izmantojot klasiskās cisteīna konjugācijas stratēģijas, tomēr tās noved pie neviendabīguma, neoptimālas efektivitātes un farmakokinētikas.

Šeit mēs aprakstām to heterobifunkcionālo saišu dizainu, sintēzi un apstiprināšanu, kuras var izmantot ADC ar divu, trīs un Four DAR sagatavošanai, katrai vietnei raksturīgā metodē vienā cisteīna konjugācijas vietnē, kas noved pie vietnei specifiskiem ADC ar DAR 4, seši un astoņi. Izstrādātie saites satur sulfhidrilam raksturīgu jodoacetilreaktīvu grupu un vairākas cikliskas diēna daļas, kas, izmantojot Dīla-Aldera reakciju, varētu efektīvi reaģēt ar lietderīgo slodzi ar maleimīdu nesošajām kravām.

 Kā idejas pierādījumu mēs sintezējām vietnei specifiskus DAR 4, sešus un astoņus ADC, kas satur tubulizīnu (AZ13601508), izmantojot inženierijas antivielas ar cisteīnu, kas ievietots aiz 239. vietas antivielu CH2 zonā.

Mēs novērtējām un atšķirībā no tā ADC in vitro citotoksicitāti, kas iegūta, izmantojot šeit aprakstīto vietnei specifisko platformu, ar ADC, kas gatavi izmantot klasisko cisteīna konjugāciju. Mūsu zināšanas apstiprināja jaunu konjugācijas platformu, kuras pamatā ir cisteīns, vietnei specifisku ADC sagatavošanai ar pārmērīgu zāļu slodzi terapeitiskos nolūkos.

 

Protectin (CD59) Monoclonal Antibody (Rabbit), PE

4-MAB336Rb21-PE
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Description: A Mouse monoclonal antibody against Rabbit Protectin (CD59). This antibody is labeled with PE.

Protectin (CD59) Monoclonal Antibody (Rabbit), APC

4-MAB336Rb21-APC
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Description: A Mouse monoclonal antibody against Rabbit Protectin (CD59). This antibody is labeled with APC.

Protectin (CD59) Monoclonal Antibody (Rabbit), Cy3

4-MAB336Rb21-Cy3
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Description: A Mouse monoclonal antibody against Rabbit Protectin (CD59). This antibody is labeled with Cy3.

Protectin (CD59) Monoclonal Antibody (Rabbit), HRP

4-MAB336Rb21-HRP
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Description: A Mouse monoclonal antibody against Rabbit Protectin (CD59). This antibody is labeled with HRP.

Protectin (CD59) Monoclonal Antibody (Rabbit), FITC

4-MAB336Rb21-FITC
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  • 100ul
  • 10ml
  • 1ml
  • 200ul
  • 20ul
Description: A Mouse monoclonal antibody against Rabbit Protectin (CD59). This antibody is labeled with FITC.

CD59 / Complement Regulatory Protein / Protectin Mouse Monoclonal Antibody

MBS438578-002mgWithBSAAzideat02mgmL 0.02mg(WithBSA&Azideat0.2mg/mL)
EUR 230

CD59 / Complement Regulatory Protein / Protectin Mouse Monoclonal Antibody

MBS438578-01mgWithBSAAzideat02mgmL 0.1mg(WithBSA&Azideat0.2mg/mL)
EUR 405

CD59 / Complement Regulatory Protein / Protectin Mouse Monoclonal Antibody

MBS438578-01mgWithoutBSAAzideat1mgmL 0.1mg(WithoutBSA&Azideat1mg/mL)
EUR 405

CD59 / Complement Regulatory Protein / Protectin Mouse Monoclonal Antibody

MBS438578-5x01mgWithBSAAzideat02mgmL 5x0.1mg(WithBSA&Azideat0.2mg/mL)
EUR 1725

CD59 / Complement Regulatory Protein / Protectin Mouse Monoclonal Antibody

MBS438578-5x01mgWithoutBSAAzideat1mgmL 5x0.1mg(WithoutBSA&Azideat1mg/mL)
EUR 1725

CD59 / Complement Regulatory Protein / Protectin Mouse Monoclonal Antibody

MBS438637-002mgWithBSAAzideat02mgmL 0.02mg(WithBSA&Azideat0.2mg/mL)
EUR 230

CD59 / Complement Regulatory Protein / Protectin Mouse Monoclonal Antibody

MBS438637-01mgWithBSAAzideat02mgmL 0.1mg(WithBSA&Azideat0.2mg/mL)
EUR 405

CD59 / Complement Regulatory Protein / Protectin Mouse Monoclonal Antibody

MBS438637-01mgWithoutBSAat1mgmL 0.1mg(WithoutBSAat1mg/mL)
EUR 405

CD59 / Complement Regulatory Protein / Protectin Mouse Monoclonal Antibody

MBS438637-5x01mgWithBSAAzideat02mgmL 5x0.1mg(WithBSA&Azideat0.2mg/mL)
EUR 1725

CD59 / Complement Regulatory Protein / Protectin Mouse Monoclonal Antibody

MBS438637-5x01mgWithoutBSAat1mgmL 5x0.1mg(WithoutBSAat1mg/mL)
EUR 1725

CD59 / Complement Regulatory Protein / Protectin Mouse Monoclonal Antibody

MBS439044-002mgWithBSAAzideat02mgmL 0.02mg(WithBSA&Azideat0.2mg/mL)
EUR 230

CD59 / Complement Regulatory Protein / Protectin Mouse Monoclonal Antibody

MBS439044-01mgWithBSAAzideat02mgmL 0.1mg(WithBSA&Azideat0.2mg/mL)
EUR 405

CD59 / Complement Regulatory Protein / Protectin Mouse Monoclonal Antibody

MBS439044-01mgWithoutBSAat1mgmL 0.1mg(WithoutBSAat1mg/mL)
EUR 405

CD59 / Complement Regulatory Protein / Protectin Mouse Monoclonal Antibody

MBS439044-5x01mgWithBSAAzideat02mgmL 5x0.1mg(WithBSA&Azideat0.2mg/mL)
EUR 1725

CD59 / Complement Regulatory Protein / Protectin Mouse Monoclonal Antibody

MBS439044-5x01mgWithoutBSAat1mgmL 5x0.1mg(WithoutBSAat1mg/mL)
EUR 1725

CD59 / Complement Regulatory Protein / Protectin Mouse Monoclonal Antibody

MBS439480-002mgWithBSAAzideat02mgmL 0.02mg(WithBSA&Azideat0.2mg/mL)
EUR 230

CD59 / Complement Regulatory Protein / Protectin Mouse Monoclonal Antibody

MBS439480-01mgWithBSAAzideat02mgmL 0.1mg(WithBSA&Azideat0.2mg/mL)
EUR 405

CD59 / Complement Regulatory Protein / Protectin Mouse Monoclonal Antibody

MBS439480-01mgWithoutBSAAzideat1mgmL 0.1mg(WithoutBSA&Azideat1mg/mL)
EUR 405

CD59 / Complement Regulatory Protein / Protectin Mouse Monoclonal Antibody

MBS439480-5x01mgWithBSAAzideat02mgmL 5x0.1mg(WithBSA&Azideat0.2mg/mL)
EUR 1725

CD59 / Complement Regulatory Protein / Protectin Mouse Monoclonal Antibody

MBS439480-5x01mgWithoutBSAAzideat1mgmL 5x0.1mg(WithoutBSA&Azideat1mg/mL)
EUR 1725

CD59 / Complement Regulatory Protein / Protectin Mouse Monoclonal Antibody

MBS439648-002mgWithBSAAzideat02mgmL 0.02mg(WithBSA&Azideat0.2mg/mL)
EUR 230

CD59 / Complement Regulatory Protein / Protectin Mouse Monoclonal Antibody

MBS439648-01mgWithBSAAzideat02mgmL 0.1mg(WithBSA&Azideat0.2mg/mL)
EUR 405

CD59 / Complement Regulatory Protein / Protectin Mouse Monoclonal Antibody

MBS439648-01mgWithoutBSAAzideat1mgmL 0.1mg(WithoutBSA&Azideat1mg/mL)
EUR 405

CD59 / Complement Regulatory Protein / Protectin Mouse Monoclonal Antibody

MBS439648-5x01mgWithBSAAzideat02mgmL 5x0.1mg(WithBSA&Azideat0.2mg/mL)
EUR 1725

CD59 / Complement Regulatory Protein / Protectin Mouse Monoclonal Antibody

MBS439648-5x01mgWithoutBSAAzideat1mgmL 5x0.1mg(WithoutBSA&Azideat1mg/mL)
EUR 1725

Protectin (CD59) Monoclonal Antibody (Rabbit), Biotinylated

4-MAB336Rb21-Biotin
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  • 100ul
  • 10ml
  • 1ml
  • 200ul
  • 20ul
Description: A Mouse monoclonal antibody against Rabbit Protectin (CD59). This antibody is labeled with Biotin.

PE-Linked Monoclonal Antibody to Protectin (CD59)

MBS2108629-INQUIRE INQUIRE Ask for price

APC-Linked Monoclonal Antibody to Protectin (CD59)

MBS2108630-INQUIRE INQUIRE Ask for price

Cy3-Linked Monoclonal Antibody to Protectin (CD59)

MBS2108631-INQUIRE INQUIRE Ask for price

HRP-Linked Monoclonal Antibody to Protectin (CD59)

MBS2108634-INQUIRE INQUIRE Ask for price

Protectin (CD59) Monoclonal Antibody (Rabbit), APC-Cy7

4-MAB336Rb21-APC-Cy7
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  • 100ul
  • 10ml
  • 1ml
  • 200ul
  • 20ul
Description: A Mouse monoclonal antibody against Rabbit Protectin (CD59). This antibody is labeled with APC-Cy7.

FITC-Linked Monoclonal Antibody to Protectin (CD59)

MBS2108633-INQUIRE INQUIRE Ask for price

Botin-Linked Monoclonal Antibody to Protectin (CD59)

MBS2108632-INQUIRE INQUIRE Ask for price

APC/Cy7 Linked Monoclonal Antibody to Protectin (CD59)

MBS2108628-INQUIRE INQUIRE Ask for price

Anti-CD59 / Complement Regulatory Protein / Protectin Monoclonal Antibody

M00914 100ug/vial
EUR 476.4
Description: Mouse Monoclonal CD59 / Complement Regulatory Protein / Protectin Antibody. Validated in IF, IHC and tested in Human.

Monoclonal CD59 / Complement Regulatory Protein / Protectin Antibody, Clone: MACIF/629

AMM01596G 7 ml
EUR 580.8
Description: A Monoclonal antibody against Human CD59 / Complement Regulatory Protein / Protectin. The antibodies are raised in Mouse and are from clone MACIF/629. This antibody is applicable in IHC, IF, FC

Monoclonal CD59 / Complement Regulatory Protein / Protectin Antibody, Clone: MACIF/1193

AMM01601G 7 ml
EUR 580.8
Description: A Monoclonal antibody against Human CD59 / Complement Regulatory Protein / Protectin. The antibodies are raised in Mouse and are from clone MACIF/1193. This antibody is applicable in IHC, IF, FC

CD59/Complement Regulatory Protein/Protectin Recombinant Rabbit Monoclonal Antibody [Clone MACIF/7021R]

MBS4382418-002mgWithBSAAzideat02mgmL 0.02mg(WithBSA&Azideat0.2mg/mL)
EUR 230

CD59/Complement Regulatory Protein/Protectin Recombinant Rabbit Monoclonal Antibody [Clone MACIF/7021R]

MBS4382418-01mgWithBSAAzideat02mgmL 0.1mg(WithBSA&Azideat0.2mg/mL)
EUR 405

CD59/Complement Regulatory Protein/Protectin Recombinant Rabbit Monoclonal Antibody [Clone MACIF/7021R]

MBS4382418-01mgWithoutBSAAzideat1mgmL 0.1mg(WithoutBSA&Azideat1mg/mL)
EUR 405

CD59/Complement Regulatory Protein/Protectin Recombinant Rabbit Monoclonal Antibody [Clone MACIF/7021R]

MBS4382418-5x01mgWithBSAAzideat02mgmL 5x0.1mg(WithBSA&Azideat0.2mg/mL)
EUR 1725

CD59/Complement Regulatory Protein/Protectin Recombinant Rabbit Monoclonal Antibody [Clone MACIF/7021R]

MBS4382418-5x01mgWithoutBSAAzideat1mgmL 5x0.1mg(WithoutBSA&Azideat1mg/mL)
EUR 1725

Monoclonal CD59 / Complement Regulatory Protein / Protectin Antibody - With BSA and Azide, Clone: SPM616

AMM01599G 0.05mg
EUR 475.2
Description: A Monoclonal antibody against Human CD59 / Complement Regulatory Protein / Protectin - With BSA and Azide. The antibodies are raised in Mouse and are from clone SPM616. This antibody is applicable in IHC, IF, FC

Monoclonal CD59 / Complement Regulatory Protein / Protectin Antibody - With BSA and Azide, Clone: 193-27

AMM01592G 0.05mg
EUR 475.2
Description: A Monoclonal antibody against Human CD59 / Complement Regulatory Protein / Protectin - With BSA and Azide. The antibodies are raised in Mouse and are from clone 193-27. This antibody is applicable in IF, FC

Monoclonal CD59 / Complement Regulatory Protein / Protectin Antibody - Without BSA and Azide, Clone: SPM616

AMM01600G 0.1mg
EUR 580.8
Description: A Monoclonal antibody against Human CD59 / Complement Regulatory Protein / Protectin - Without BSA and Azide. The antibodies are raised in Mouse and are from clone SPM616. This antibody is applicable in IHC, IF, FC

Monoclonal CD59 / Complement Regulatory Protein / Protectin Antibody - Without BSA and Azide, Clone: 193-27

AMM01593G 0.1mg
EUR 580.8
Description: A Monoclonal antibody against Human CD59 / Complement Regulatory Protein / Protectin - Without BSA and Azide. The antibodies are raised in Mouse and are from clone 193-27. This antibody is applicable in IF, FC

Monoclonal CD59 / Complement Regulatory Protein / Protectin Antibody - With BSA and Azide, Clone: BRA-10G

AMM01594G 0.05mg
EUR 475.2
Description: A Monoclonal antibody against Human CD59 / Complement Regulatory Protein / Protectin - With BSA and Azide. The antibodies are raised in Mouse and are from clone BRA-10G. This antibody is applicable in IF, FC

Monoclonal CD59 / Complement Regulatory Protein / Protectin Antibody - With BSA and Azide, Clone: MACIF/629

AMM01597G 0.05mg
EUR 475.2
Description: A Monoclonal antibody against Human CD59 / Complement Regulatory Protein / Protectin - With BSA and Azide. The antibodies are raised in Mouse and are from clone MACIF/629. This antibody is applicable in IHC, IF, FC

Monoclonal CD59 / Complement Regulatory Protein / Protectin Antibody - With BSA and Azide, Clone: MACIF/1193

AMM01602G 0.05mg
EUR 475.2
Description: A Monoclonal antibody against Human CD59 / Complement Regulatory Protein / Protectin - With BSA and Azide. The antibodies are raised in Mouse and are from clone MACIF/1193. This antibody is applicable in IHC, IF, FC

Monoclonal CD59 / Complement Regulatory Protein / Protectin Antibody - Without BSA and Azide, Clone: BRA-10G

AMM01595G 0.1mg
EUR 580.8
Description: A Monoclonal antibody against Human CD59 / Complement Regulatory Protein / Protectin - Without BSA and Azide. The antibodies are raised in Mouse and are from clone BRA-10G. This antibody is applicable in IF, FC

Monoclonal CD59 / Complement Regulatory Protein / Protectin Antibody - Without BSA and Azide, Clone: MACIF/629

AMM01598G 0.1mg
EUR 580.8
Description: A Monoclonal antibody against Human CD59 / Complement Regulatory Protein / Protectin - Without BSA and Azide. The antibodies are raised in Mouse and are from clone MACIF/629. This antibody is applicable in IHC, IF, FC

Monoclonal CD59 / Complement Regulatory Protein / Protectin Antibody - Without BSA and Azide, Clone: MACIF/1193

AMM01603G 0.1mg
EUR 580.8
Description: A Monoclonal antibody against Human CD59 / Complement Regulatory Protein / Protectin - Without BSA and Azide. The antibodies are raised in Mouse and are from clone MACIF/1193. This antibody is applicable in IHC, IF, FC

Protectin (CD59) Polyclonal Antibody (Mouse)

4-PAB336Mu01
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  • 100ul
  • 10ml
  • 1ml
  • 200ul
  • 20ul
Description: A Rabbit polyclonal antibody against Mouse Protectin (CD59)

Protectin (CD59) Polyclonal Antibody (Mouse), PE

4-PAB336Mu01-PE
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  • 100ul
  • 10ml
  • 1ml
  • 200ul
  • 20ul
Description: A Rabbit polyclonal antibody against Mouse Protectin (CD59). This antibody is labeled with PE.

Protectin (CD59) Polyclonal Antibody (Mouse), APC

4-PAB336Mu01-APC
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  • 100ul
  • 10ml
  • 1ml
  • 200ul
  • 20ul
Description: A Rabbit polyclonal antibody against Mouse Protectin (CD59). This antibody is labeled with APC.

Protectin (CD59) Polyclonal Antibody (Mouse), Cy3

4-PAB336Mu01-Cy3
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  • 100ul
  • 10ml
  • 1ml
  • 200ul
  • 20ul
Description: A Rabbit polyclonal antibody against Mouse Protectin (CD59). This antibody is labeled with Cy3.

Protectin (CD59) Polyclonal Antibody (Mouse), HRP

4-PAB336Mu01-HRP
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  • 100ul
  • 10ml
  • 1ml
  • 200ul
  • 20ul
Description: A Rabbit polyclonal antibody against Mouse Protectin (CD59). This antibody is labeled with HRP.

Protectin (CD59) Polyclonal Antibody (Mouse), FITC

4-PAB336Mu01-FITC
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  • 100ul
  • 10ml
  • 1ml
  • 200ul
  • 20ul
Description: A Rabbit polyclonal antibody against Mouse Protectin (CD59). This antibody is labeled with FITC.

Protectin (CD59) Antibody

20-abx109633
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  • 100 ug
  • 1 mg
  • 200 ug
  • 20 ug
  • 50 ug

Protectin (CD59) Antibody

20-abx109634
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  • 100 ug
  • 1 mg
  • 200 ug
  • 20 ug
  • 50 ug

Protectin (CD59) Antibody

20-abx111491
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  • 150 ul
  • 50 ul

Protectin (CD59) Antibody

20-abx100397
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  • 100 ug
  • 10 ug
  • 1 mg
  • 200 ug
  • 50 ug

Protectin (CD59) Antibody

20-abx100398
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  • 100 ug
  • 10 ug
  • 1 mg
  • 200 ug
  • 50 ug

Protectin (CD59) Antibody

20-abx100399
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  • 100 ug
  • 10 ug
  • 1 mg
  • 200 ug
  • 50 ug

Protectin (CD59) Antibody

20-abx100400
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  • 100 ug
  • 10 ug
  • 1 mg
  • 200 ug
  • 50 ug

Protectin (CD59) Antibody

20-abx100401
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  • 100 ug
  • 10 ug
  • 1 mg
  • 200 ug
  • 50 ug

Protectin (CD59) Antibody

20-abx100402
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  • 100 ug
  • 10 ug
  • 1 mg
  • 200 ug
  • 50 ug

Protectin (CD59) Antibody

20-abx132385
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  • 100 ug
  • 1 mg
  • 200 ug
  • 20 ug
  • 50 ug

Protectin (CD59) Antibody

abx139305-01mg 0.1 mg
EUR 427.2

Protectin (CD59) Antibody

abx139306-01mg 0.1 mg
EUR 444

Protectin (CD59) Antibody

abx139307-01mg 0.1 mg
EUR 427.2

Protectin (CD59) Antibody

abx036096-100ug 100 ug
EUR 469.2

Protectin (CD59) Antibody

abx021467-100ug 100 ug
EUR 543.6

Protectin (CD59) Antibody

abx011952-100ug 100 ug
EUR 493.2

Protectin (CD59) Antibody

20-abx001417
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  • 100 ul
  • 200 ul
  • 50 ul

Protectin (CD59) Antibody

abx200391-100ug 100 ug
EUR 393.6

Protectin (CD59) Antibody

20-abx210170
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  • 100 ug
  • 50 ug

Protectin (CD59) Antibody

20-abx210424
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  • 100 ul
  • 50 ul

Protectin (CD59) Antibody

20-abx270064
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  • 100 tests
  • 200 tests
  • 25 tests
  • 500 tests
  • 50 tests

Protectin (CD59) Antibody

abx231489-100ug 100 ug
EUR 577.2

Protectin (CD59) Antibody

20-abx174238
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  • 1 mg
  • 200 ug

Protectin (CD59) Antibody

20-abx225094
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  • 100 ul
  • 200 ul
  • 50 ul

Protectin (CD59) Antibody

20-abx178138
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  • 100 ug
  • 10 ug
  • 1 mg
  • 200 ug
  • 50 ug

Protectin (CD59) Antibody

20-abx323672
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  • 100 ug
  • 50 ug

Protectin (CD59) Antibody

20-abx339758
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  • 100 ul
  • 50 ul

Protectin (CD59) Polyclonal Antibody (Mouse), Biotinylated

4-PAB336Mu01-Biotin
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  • 100ul
  • 10ml
  • 1ml
  • 200ul
  • 20ul
Description: A Rabbit polyclonal antibody against Mouse Protectin (CD59). This antibody is labeled with Biotin.

Protectin (CD59) Polyclonal Antibody (Mouse), APC-Cy7

4-PAB336Mu01-APC-Cy7
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  • 100ul
  • 10ml
  • 1ml
  • 200ul
  • 20ul
Description: A Rabbit polyclonal antibody against Mouse Protectin (CD59). This antibody is labeled with APC-Cy7.

Protectin (CD59) Antibody (PE)

abx139308-100tests 100 tests
EUR 577.2

Protectin (CD59) Antibody (PE)

abx200390-100tests 100 tests
EUR 661.2

Protectin (CD59) Antibody (PE)

abx200393-100tests 100 tests
EUR 543.6

Protectin (CD59) Antibody (PE)

20-abx270826
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  • 100 tests
  • 200 tests
  • 25 tests
  • 500 tests
  • 50 tests

Protectin (CD59) Antibody (HRP)

20-abx108081
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  • 100 ug
  • 1 mg
  • 200 ug
  • 20 ug
  • 50 ug

Protectin (CD59) Antibody (HRP)

20-abx108082
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  • 100 ug
  • 1 mg
  • 200 ug
  • 20 ug
  • 50 ug

Protectin (CD59) Antibody (APC)

abx139309-100tests 100 tests
EUR 577.2

Protectin (CD59) Antibody (APC)

abx200394-100tests 100 tests
EUR 543.6

Protectin (CD59) Antibody (APC)

20-abx270594
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  • 100 tests
  • 200 tests
  • 25 tests
  • 500 tests
  • 50 tests

Protectin (CD59) Antibody (RPE)

abx412706-100tests 100 tests
EUR 710.4

Protectin (CD59) Antibody (RPE)

abx412707-25tests025ml 25 tests (0.25 ml)
EUR 376.8

Protectin (CD59) Antibody (RPE)

abx413501-100tests 100 tests
EUR 710.4

Protectin (CD59) Antibody (RPE)

abx413502-25tests 25 tests
EUR 376.8

Protectin (CD59) Antibody (RPE)

abx415434-100tests 100 tests
EUR 710.4

Protectin (CD59) Antibody (FITC)

20-abx106664
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  • 100 ug
  • 1 mg
  • 200 ug
  • 20 ug
  • 50 ug

Protectin (CD59) Antibody (FITC)

20-abx106665
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  • 100 ug
  • 1 mg
  • 200 ug
  • 20 ug
  • 50 ug

Protectin (CD59) Antibody (FITC)

abx134463-100Assays 100 Assays
EUR 526.8

Protectin (CD59) Antibody (FITC)

abx134463-50Assays 50 Assays
EUR 410.4

Protectin (CD59) Antibody (FITC)

abx139311-100tests 100 tests
EUR 510

Protectin (CD59) Antibody (FITC)

abx200392-100tests 100 tests
EUR 477.6

Protectin (CD59) Antibody (FITC)

20-abx270362
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  • 100 tests
  • 200 tests
  • 25 tests
  • 500 tests
  • 50 tests

Protectin (CD59) Antibody (PerCP)

abx200395-100tests 100 tests
EUR 543.6

Anti-Human CD59 (Protectin) Antibody

MBS4159564-01mL 0.1mL
EUR 590

Anti-Human CD59 (Protectin) Antibody

MBS4159564-5x01mL 5x0.1mL
EUR 2395

Protectin (CD59) Antibody (Biotin)

20-abx105246
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  • 100 ug
  • 1 mg
  • 200 ug
  • 20 ug
  • 50 ug

Protectin (CD59) Antibody (Biotin)

20-abx105247
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  • 100 ug
  • 1 mg
  • 200 ug
  • 20 ug
  • 50 ug

Protectin (CD59) Antibody (Biotin)

abx139310-01mg 0.1 mg
EUR 510

Protectin (CD59) Antibody (Biotin)

abx200396-100ug 100 ug
EUR 460.8

Protectin (CD59) Antibody (Biotin)

20-abx272126
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  • 100 ug
  • 10 ug
  • 1 mg
  • 200 ug
  • 50 ug

Protectin (CD59) Antibody (Biotin)

20-abx272910
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  • 100 ug
  • 10 ug
  • 1 mg
  • 200 ug
  • 50 ug

Protectin (CD59) Antibody (Biotin)

20-abx273046
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  • 100 ug
  • 10 ug
  • 1 mg
  • 200 ug
  • 50 ug

Protectin (CD59) Antibody (Biotin)

20-abx273328
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  • 100 ug
  • 10 ug
  • 1 mg
  • 200 ug
  • 50 ug

Protectin (CD59) Antibody (Biotin)

20-abx273444
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  • 100 ug
  • 10 ug
  • 1 mg
  • 200 ug
  • 50 ug

Mouse Protectin (CD59) Protein

20-abx068726
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  • 100 ug
  • 10 ug
  • 1 mg
  • 200 ug
  • 50 ug

Protectin (CD59) Antibody (OC-515)

abx200398-100tests 100 tests
EUR 543.6

Protectin (CD59) Antibody (CF-Blue)

abx200397-100tests 100 tests
EUR 577.2

Polyclonal Antibody to Protectin (CD59)

MBS2002399-01mL 0.1mL
EUR 190

Polyclonal Antibody to Protectin (CD59)

MBS2002399-02mL 0.2mL
EUR 235

Polyclonal Antibody to Protectin (CD59)

MBS2002399-05mL 0.5mL
EUR 400

Polyclonal Antibody to Protectin (CD59)

MBS2002399-1mL 1mL
EUR 485

Polyclonal Antibody to Protectin (CD59)

MBS2002399-5mL 5mL
EUR 1345

Polyclonal Antibody to Protectin (CD59)

MBS2002941-01mL 0.1mL
EUR 195

Polyclonal Antibody to Protectin (CD59)

MBS2002941-02mL 0.2mL
EUR 240

Polyclonal Antibody to Protectin (CD59)

MBS2002941-05mL 0.5mL
EUR 425

Polyclonal Antibody to Protectin (CD59)

MBS2002941-1mL 1mL
EUR 515

Polyclonal Antibody to Protectin (CD59)

MBS2002941-5mL 5mL
EUR 1440

Polyclonal Antibody to Protectin (CD59)

MBS2004913-01mL 0.1mL
EUR 170

Polyclonal Antibody to Protectin (CD59)

MBS2004913-02mL 0.2mL
EUR 205

Polyclonal Antibody to Protectin (CD59)

MBS2004913-05mL 0.5mL
EUR 335

Polyclonal Antibody to Protectin (CD59)

MBS2004913-1mL 1mL
EUR 415

Polyclonal Antibody to Protectin (CD59)

MBS2004913-5mL 5mL
EUR 1130

Polyclonal Antibody to Protectin (CD59)

MBS2006169-01mL 0.1mL
EUR 175

Polyclonal Antibody to Protectin (CD59)

MBS2006169-02mL 0.2mL
EUR 220

Polyclonal Antibody to Protectin (CD59)

MBS2006169-05mL 0.5mL
EUR 365

Polyclonal Antibody to Protectin (CD59)

MBS2006169-1mL 1mL
EUR 445

Polyclonal Antibody to Protectin (CD59)

MBS2006169-5mL 5mL
EUR 1225

Polyclonal Antibody to Protectin (CD59)

MBS2006950-01mL 0.1mL
EUR 175

Polyclonal Antibody to Protectin (CD59)

MBS2006950-02mL 0.2mL
EUR 220

Polyclonal Antibody to Protectin (CD59)

MBS2006950-05mL 0.5mL
EUR 365

Polyclonal Antibody to Protectin (CD59)

MBS2006950-1mL 1mL
EUR 445

Polyclonal Antibody to Protectin (CD59)

MBS2006950-5mL 5mL
EUR 1225

Polyclonal Antibody to Protectin (CD59)

MBS2005216-01mL 0.1mL
EUR 170

Polyclonal Antibody to Protectin (CD59)

MBS2005216-02mL 0.2mL
EUR 215

Polyclonal Antibody to Protectin (CD59)

MBS2005216-05mL 0.5mL
EUR 350

Polyclonal Antibody to Protectin (CD59)

MBS2005216-1mL 1mL
EUR 425

Polyclonal Antibody to Protectin (CD59)

MBS2005216-5mL 5mL
EUR 1160

Protectin (CD59) Polyclonal Antibody (Pig)

4-PAB336Po01
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  • 100ul
  • 10ml
  • 1ml
  • 200ul
  • 20ul
Description: A Rabbit polyclonal antibody against Pig Protectin (CD59)

Protectin (CD59) Polyclonal Antibody (Rat)

4-PAB336Ra01
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  • 100ul
  • 10ml
  • 1ml
  • 200ul
  • 20ul
Description: A Rabbit polyclonal antibody against Rat Protectin (CD59)

Protectin (CD59) Polyclonal Antibody (Human)

4-PAB336Hu01
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  • 100ul
  • 10ml
  • 1ml
  • 200ul
  • 20ul
Description: A Rabbit polyclonal antibody against Human Protectin (CD59)

Protectin (CD59) Polyclonal Antibody (Human)

4-PAB336Si01
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  • 100ul
  • 10ml
  • 1ml
  • 200ul
  • 20ul
Description: A Rabbit polyclonal antibody against Human Protectin (CD59)

Mouse Protectin (CD59) CLIA Kit

20-abx492660
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  • 10 × 96 tests
  • 5 × 96 tests
  • 96 tests

Mouse Protectin (CD59) ELISA Kit

DLR-CD59-Mu 96T
EUR 454
Description: serum, plasma, urine or other biological fluids.

Mouse Protectin (CD59) ELISA Kit

DLR-CD59-Mu-48T 48T
EUR 609.6
Description: A sandwich quantitative ELISA assay kit for detection of Mouse Protectin (CD59) in samples from serum, plasma, urine or other biological fluids.

Mouse Protectin (CD59) ELISA Kit

DLR-CD59-Mu-96T 96T
EUR 793.2
Description: A sandwich quantitative ELISA assay kit for detection of Mouse Protectin (CD59) in samples from serum, plasma, urine or other biological fluids.

Mouse Protectin (CD59) ELISA Kit

EK13155 96Т
EUR 768

Mouse Protectin (CD59) ELISA Kit

DL-CD59-Mu 96T
EUR 432
Description: serum, plasma, urine or other biological fluids.

Mouse Protectin (CD59) ELISA Kit

RD-CD59-Mu-48T 48T
EUR 443.3
Description: serum, plasma, urine and other biological fluids.

Mouse Protectin (CD59) ELISA Kit

RD-CD59-Mu-48Tests 48 Tests
EUR 613.2

Mouse Protectin (CD59) ELISA Kit

RD-CD59-Mu-96T 96T
EUR 633.3
Description: serum, plasma, urine and other biological fluids.

Mouse Protectin (CD59) ELISA Kit

RD-CD59-Mu-96Tests 96 Tests
EUR 850.8

Mouse Protectin (CD59) ELISA Kit

RDR-CD59-Mu-48T 48T
EUR 465.47
Description: serum, plasma, urine and other biological fluids.

Mouse Protectin (CD59) ELISA Kit

RDR-CD59-Mu-48Tests 48 Tests
EUR 640.8

Mouse Protectin (CD59) ELISA Kit

RDR-CD59-Mu-96T 96T
EUR 664.97
Description: serum, plasma, urine and other biological fluids.

Mouse Protectin (CD59) ELISA Kit

RDR-CD59-Mu-96Tests 96 Tests
EUR 890.4

Mouse Protectin (CD59) ELISA Kit

SEB336Mu-10x96wellstestplate 10x96-wells test plate
EUR 5552.14
Description: This is Double-antibody Sandwich Enzyme-linked immunosorbent assay for detection of Mouse Protectin (CD59) in serum, plasma, urine and other biological fluids.

Mouse Protectin (CD59) ELISA Kit

SEB336Mu-1x48wellstestplate 1x48-wells test plate
EUR 562.42
Description: This is Double-antibody Sandwich Enzyme-linked immunosorbent assay for detection of Mouse Protectin (CD59) in serum, plasma, urine and other biological fluids.

Mouse Protectin (CD59) ELISA Kit

SEB336Mu-1x96wellstestplate 1x96-wells test plate
EUR 752.02
Description: This is Double-antibody Sandwich Enzyme-linked immunosorbent assay for detection of Mouse Protectin (CD59) in serum, plasma, urine and other biological fluids.

Mouse Protectin (CD59) ELISA Kit

SEB336Mu-5x96wellstestplate 5x96-wells test plate
EUR 3024.07
Description: This is Double-antibody Sandwich Enzyme-linked immunosorbent assay for detection of Mouse Protectin (CD59) in serum, plasma, urine and other biological fluids.

Mouse Protectin (CD59) ELISA Kit

4-SEB336Mu
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  • 10 plates of 96 wells
  • 5 plates of 96 wells
  • 1 plate of 96 wells
Description: Enzyme-linked immunosorbent assay based on the Double-antibody Sandwich method for detection of Mouse Protectin (CD59) in samples from Serum, plasma, urine and other biological fluids. with no significant corss-reactivity with analogues from other species.

Mouse Protectin (CD59) ELISA Kit

MBS2023432-10x96StripWells 10x96-Strip-Wells
EUR 5220

Mouse Protectin (CD59) ELISA Kit

MBS2023432-24StripWells 24-Strip-Wells
EUR 355

Mouse Protectin (CD59) ELISA Kit

MBS2023432-48StripWells 48-Strip-Wells
EUR 535

Mouse Protectin (CD59) ELISA Kit

MBS2023432-5x96StripWells 5x96-Strip-Wells
EUR 2860

Mouse Protectin (CD59) ELISA Kit

MBS2023432-96StripWells 96-Strip-Wells
EUR 705

Mouse Protectin (CD59) ELISA Kit

MBS458249-10x96Tests 10x96Tests
EUR 5170

Mouse Protectin (CD59) ELISA Kit

MBS458249-48Tests 48Tests
EUR 450

Mouse Protectin (CD59) ELISA Kit

MBS458249-5x96Tests 5x96Tests
EUR 2655

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