HER2 ātras internalizācijas un novirzītas cilvēku tirdzniecības molekulārais

HER2 ātras internalizācijas un novirzītas cilvēku tirdzniecības molekulārais mehānisms, ko izraisa anti-HER2 biparatopiskais antiviela

  • HER2 (cilvēka epidermas attīstības problēmas 2. receptora), ErbB2 receptoru tirozīna kināzes, pastiprināšanās un pārmērīga ekspresija ir saistīta ar lielāko daļu cilvēku vēža un metastāžu. Ir ziņots, ka bispecifiska četrvērtīga anti-HER2 antiviela (anti-HER2-Bs), kas koncentrējas uz diviem HER2 nepilējošiem epitopiem IV zonā (trastuzumabs) un II zonā (39S), izraisa ātru HER2 internalizāciju un videi draudzīgu degradāciju. receptori. 
  • Šajā pētījumā mēs izpētījām šīs antivielu izraisītās ātrās HER2 internalizācijas un intracelulārās tirdzniecības molekulāro mehānismu. Izmantojot kvantitatīvo fluorescējošo attēlveidošanu, mēs pretstatām anti-HER2-B un tā vecāku roku antivielu internalizācijas kinētikai atsevišķi vai maisījumos un daudzos internalizāciju veicinošos apstākļos. Rezultāti parādīja, ka ātrai anti-HER2-B internalizācijai izšķiroša nozīme bija vienlaicīgai katra epitopa iesaistei.
  • Anti-HER2-B un vecāku roku antivielu mobilā uzņemšana notika no klatrīna atkarīgas endocitozes veidā; tomēr antivielas šūnās satur pilnīgi atšķirīgus cilvēku tirdzniecības ceļus. Trastuzumabs 2 stundu laikā disociējās no HER2, ļaujot receptoriem atkārtoti pārstrādāt, savukārt anti-HER2-B palika saistīti ar receptoru visā endocītiskajā ceļā, pārdodot receptoru ubikvitināciju, tirdzniecību ar lizosomām un videi draudzīgu noārdīšanos.
  • Atbilstoši HER2 novirzīšanai uz degradāciju, anti-HER2-B ievērojami samazināja HER2 izdalīšanos un mainīja tā eksosomālo eksportu. Kopā šie rezultāti ļauj labāk izprast anti-Her2-B kustības mehānismu un var sniegt informāciju par racionālu anti-HER2 terapijas dizainu papildus dažādām bispecifiskām molekulām.

Cilvēkiem ar receptoru saistošās domēna specifiskās neitralizējošās monoklonālās antivielas pretstatā SARS-CoV un SARS-CoV-2

Ārkārtējā akūtā elpošanas sindroma (SARS) un 2019. gada koronavīrusa slimības (COVID-19) uzliesmojumi, ko izraisīja attiecīgi SARS-CoV un SARS-CoV-2, ir ārkārtīgi apdraudējuši pasaules sabiedrības labklājību un ekonomisko sistēmu. Šo vīrusu slimību terapija un profilakse ir cilvēka neitralizējošo monoklonālo antivielu (NMAbs) analīze un augšana.

Zinātnieki ir skrīnējuši neitralizējošās antivielas, kā antigēnu izmantojot vīrusa receptoru saistošo zonu (RBD), norādot, ka RBD ir iekļauti vairāki konformācijas neitralizējoši epitopi, kas ir galvenie strukturālie domēni neitralizējošo antivielu un T-šūnu imūnreakciju inducēšanai. Šajā novērtējumā ir apkopota RBD un RBD specifisko NMAb konstrukcija un veiktspēja, pretstatā SARS-CoV un SARS-CoV-2 pašlaik zem izaugsmes.

bernsklepo
bernsklepo

Canine Interleukin 8 (IL8) ELISA Kit

DLR-IL8-c-96T 96T
EUR 411
  • Should the Canine Interleukin 8 (IL8) ELISA Kit is proven to show malperformance, you will receive a refund or a free replacement.
Description: A sandwich quantitative ELISA assay kit for detection of Canine Interleukin 8 (IL8) in samples from serum, plasma, tissue homogenates, cell lysates, cell culture supernates or other biological fluids.

Chicken Interleukin 8 (IL8) ELISA Kit

DLR-IL8-Ch-48T 48T
EUR 413
  • Should the Chicken Interleukin 8 (IL8) ELISA Kit is proven to show malperformance, you will receive a refund or a free replacement.
Description: A sandwich quantitative ELISA assay kit for detection of Chicken Interleukin 8 (IL8) in samples from serum, plasma, tissue homogenates, cell lysates, cell culture supernates or other biological fluids.

Chicken Interleukin 8 (IL8) ELISA Kit

DLR-IL8-Ch-96T 96T
EUR 531
  • Should the Chicken Interleukin 8 (IL8) ELISA Kit is proven to show malperformance, you will receive a refund or a free replacement.
Description: A sandwich quantitative ELISA assay kit for detection of Chicken Interleukin 8 (IL8) in samples from serum, plasma, tissue homogenates, cell lysates, cell culture supernates or other biological fluids.

Equine Interleukin 8 (IL8) ELISA Kit

DLR-IL8-Eq-48T 48T
EUR 503
  • Should the Equine Interleukin 8 (IL8) ELISA Kit is proven to show malperformance, you will receive a refund or a free replacement.
Description: A sandwich quantitative ELISA assay kit for detection of Equine Interleukin 8 (IL8) in samples from serum, plasma, tissue homogenates, cell lysates, cell culture supernates or other biological fluids.

Equine Interleukin 8 (IL8) ELISA Kit

DLR-IL8-Eq-96T 96T
EUR 654
  • Should the Equine Interleukin 8 (IL8) ELISA Kit is proven to show malperformance, you will receive a refund or a free replacement.
Description: A sandwich quantitative ELISA assay kit for detection of Equine Interleukin 8 (IL8) in samples from serum, plasma, tissue homogenates, cell lysates, cell culture supernates or other biological fluids.

Fish Interleukin 8 (IL8) ELISA Kit

DLR-IL8-Fi-48T 48T
EUR 503
  • Should the Fish Interleukin 8 (IL8) ELISA Kit is proven to show malperformance, you will receive a refund or a free replacement.
Description: A sandwich quantitative ELISA assay kit for detection of Fish Interleukin 8 (IL8) in samples from serum, plasma, tissue homogenates or other biological fluids.

Fish Interleukin 8 (IL8) ELISA Kit

DLR-IL8-Fi-96T 96T
EUR 654
  • Should the Fish Interleukin 8 (IL8) ELISA Kit is proven to show malperformance, you will receive a refund or a free replacement.
Description: A sandwich quantitative ELISA assay kit for detection of Fish Interleukin 8 (IL8) in samples from serum, plasma, tissue homogenates or other biological fluids.

Human Interleukin 8 (IL8) ELISA Kit

DLR-IL8-Hu-48T 48T
EUR 333
  • Should the Human Interleukin 8 (IL8) ELISA Kit is proven to show malperformance, you will receive a refund or a free replacement.
Description: A sandwich quantitative ELISA assay kit for detection of Human Interleukin 8 (IL8) in samples from serum, plasma, tissue homogenates, cell lysates, cell culture supernates or other biological fluids.

Human Interleukin 8 (IL8) ELISA Kit

DLR-IL8-Hu-96T 96T
EUR 420
  • Should the Human Interleukin 8 (IL8) ELISA Kit is proven to show malperformance, you will receive a refund or a free replacement.
Description: A sandwich quantitative ELISA assay kit for detection of Human Interleukin 8 (IL8) in samples from serum, plasma, tissue homogenates, cell lysates, cell culture supernates or other biological fluids.

Porcine Interleukin 8 (IL8) ELISA Kit

DLR-IL8-p-48T 48T
EUR 448
  • Should the Porcine Interleukin 8 (IL8) ELISA Kit is proven to show malperformance, you will receive a refund or a free replacement.
Description: A sandwich quantitative ELISA assay kit for detection of Porcine Interleukin 8 (IL8) in samples from serum, plasma, tissue homogenates, cell lysates, cell culture supernates or other biological fluids.

Porcine Interleukin 8 (IL8) ELISA Kit

DLR-IL8-p-96T 96T
EUR 579
  • Should the Porcine Interleukin 8 (IL8) ELISA Kit is proven to show malperformance, you will receive a refund or a free replacement.
Description: A sandwich quantitative ELISA assay kit for detection of Porcine Interleukin 8 (IL8) in samples from serum, plasma, tissue homogenates, cell lysates, cell culture supernates or other biological fluids.

Rabbit Interleukin 8 (IL8) ELISA Kit

DLR-IL8-Rb-48T 48T
EUR 454
  • Should the Rabbit Interleukin 8 (IL8) ELISA Kit is proven to show malperformance, you will receive a refund or a free replacement.
Description: A sandwich quantitative ELISA assay kit for detection of Rabbit Interleukin 8 (IL8) in samples from serum, plasma, tissue homogenates, cell lysates, cell culture supernates or other biological fluids.

Rabbit Interleukin 8 (IL8) ELISA Kit

DLR-IL8-Rb-96T 96T
EUR 587
  • Should the Rabbit Interleukin 8 (IL8) ELISA Kit is proven to show malperformance, you will receive a refund or a free replacement.
Description: A sandwich quantitative ELISA assay kit for detection of Rabbit Interleukin 8 (IL8) in samples from serum, plasma, tissue homogenates, cell lysates, cell culture supernates or other biological fluids.

Monkey Interleukin 8 (IL8) ELISA Kit

DLR-IL8-Si-48T 48T
EUR 474
  • Should the Monkey Interleukin 8 (IL8) ELISA Kit is proven to show malperformance, you will receive a refund or a free replacement.
Description: A sandwich quantitative ELISA assay kit for detection of Monkey Interleukin 8 (IL8) in samples from serum, plasma, tissue homogenates, cell lysates, cell culture supernates or other biological fluids.

Monkey Interleukin 8 (IL8) ELISA Kit

DLR-IL8-Si-96T 96T
EUR 614
  • Should the Monkey Interleukin 8 (IL8) ELISA Kit is proven to show malperformance, you will receive a refund or a free replacement.
Description: A sandwich quantitative ELISA assay kit for detection of Monkey Interleukin 8 (IL8) in samples from serum, plasma, tissue homogenates, cell lysates, cell culture supernates or other biological fluids.

Bovine Interleukin 8 (IL8) ELISA Kit

RDR-IL8-b-48Tests 48 Tests
EUR 409

Bovine Interleukin 8 (IL8) ELISA Kit

RDR-IL8-b-96Tests 96 Tests
EUR 563

Canine Interleukin 8 (IL8) ELISA Kit

RDR-IL8-c-48Tests 48 Tests
EUR 318

Canine Interleukin 8 (IL8) ELISA Kit

RDR-IL8-c-96Tests 96 Tests
EUR 433

Chicken Interleukin 8 (IL8) ELISA Kit

RDR-IL8-Ch-48Tests 48 Tests
EUR 422

Chicken Interleukin 8 (IL8) ELISA Kit

RDR-IL8-Ch-96Tests 96 Tests
EUR 581

Equine Interleukin 8 (IL8) ELISA Kit

RDR-IL8-Eq-48Tests 48 Tests
EUR 528

Equine Interleukin 8 (IL8) ELISA Kit

RDR-IL8-Eq-96Tests 96 Tests
EUR 733

Fish Interleukin 8 (IL8) ELISA Kit

RDR-IL8-Fi-48Tests 48 Tests
EUR 528

Fish Interleukin 8 (IL8) ELISA Kit

RDR-IL8-Fi-96Tests 96 Tests
EUR 733

Human Interleukin 8 (IL8) ELISA Kit

RDR-IL8-Hu-48Tests 48 Tests
EUR 326

Human Interleukin 8 (IL8) ELISA Kit

RDR-IL8-Hu-96Tests 96 Tests
EUR 445

Porcine Interleukin 8 (IL8) ELISA Kit

RDR-IL8-p-48Tests 48 Tests
EUR 463

Porcine Interleukin 8 (IL8) ELISA Kit

RDR-IL8-p-96Tests 96 Tests
EUR 640

Rabbit Interleukin 8 (IL8) ELISA Kit

RDR-IL8-Rb-48Tests 48 Tests
EUR 470

Rabbit Interleukin 8 (IL8) ELISA Kit

RDR-IL8-Rb-96Tests 96 Tests
EUR 651

Monkey Interleukin 8 (IL8) ELISA Kit

RDR-IL8-Si-48Tests 48 Tests
EUR 493

Monkey Interleukin 8 (IL8) ELISA Kit

RDR-IL8-Si-96Tests 96 Tests
EUR 683

Bovine Interleukin 8 (IL8) ELISA Kit

RD-IL8-b-48Tests 48 Tests
EUR 392

Bovine Interleukin 8 (IL8) ELISA Kit

RD-IL8-b-96Tests 96 Tests
EUR 539

Canine Interleukin 8 (IL8) ELISA Kit

RD-IL8-c-48Tests 48 Tests
EUR 305

Canine Interleukin 8 (IL8) ELISA Kit

RD-IL8-c-96Tests 96 Tests
EUR 415

Chicken Interleukin 8 (IL8) ELISA Kit

RD-IL8-Ch-48Tests 48 Tests
EUR 404

Chicken Interleukin 8 (IL8) ELISA Kit

RD-IL8-Ch-96Tests 96 Tests
EUR 556

Equine Interleukin 8 (IL8) ELISA Kit

RD-IL8-Eq-48Tests 48 Tests
EUR 505

Equine Interleukin 8 (IL8) ELISA Kit

RD-IL8-Eq-96Tests 96 Tests
EUR 700

Human Interleukin 8 (IL8) ELISA Kit

RD-IL8-Hu-48Tests 48 Tests
EUR 313

Human Interleukin 8 (IL8) ELISA Kit

RD-IL8-Hu-96Tests 96 Tests
EUR 426

Porcine Interleukin 8 (IL8) ELISA Kit

RD-IL8-p-48Tests 48 Tests
EUR 443

Porcine Interleukin 8 (IL8) ELISA Kit

RD-IL8-p-96Tests 96 Tests
EUR 612

Rabbit Interleukin 8 (IL8) ELISA Kit

RD-IL8-Rb-48Tests 48 Tests
EUR 450

Rabbit Interleukin 8 (IL8) ELISA Kit

RD-IL8-Rb-96Tests 96 Tests
EUR 622

Monkey Interleukin 8 (IL8) ELISA Kit

RD-IL8-Si-48Tests 48 Tests
EUR 472

Monkey Interleukin 8 (IL8) ELISA Kit

RD-IL8-Si-96Tests 96 Tests
EUR 653

Interleukin 8 (IL8) Monoclonal Antibody (Horse)

4-MAA080Eq21
  • EUR 271.00
  • EUR 2892.00
  • EUR 712.00
  • EUR 344.00
  • EUR 224.00
  • 100ul
  • 10ml
  • 1ml
  • 200ul
  • 20ul
  • Sequence of the immunogen: Ala23~Pro101
  • Buffer composition: 0.01M PBS, pH7.4, containing 0.05% Proclin-300, 50% glycerol.
Description: A Mouse monoclonal antibody against Horse Interleukin 8 (IL8)

Interleukin 8 (IL8) Monoclonal Antibody (Chicken)

4-MAA080Ga22
  • EUR 236.00
  • EUR 2338.00
  • EUR 586.00
  • EUR 294.00
  • EUR 209.00
  • 100ul
  • 10ml
  • 1ml
  • 200ul
  • 20ul
  • Sequence of the immunogen: Ala17~Leu103
  • Buffer composition: 0.01M PBS, pH7.4, containing 0.05% Proclin-300, 50% glycerol.
Description: A Mouse monoclonal antibody against Chicken Interleukin 8 (IL8)

Interleukin 8 (IL8) Monoclonal Antibody (Human)

4-MAA080Hu22
  • EUR 221.00
  • EUR 2114.00
  • EUR 535.00
  • EUR 274.00
  • EUR 203.00
  • 100ul
  • 10ml
  • 1ml
  • 200ul
  • 20ul
  • Sequence of the immunogen: Ser28~Ser99
  • Buffer composition: 0.01M PBS, pH7.4, containing 0.05% Proclin-300, 50% glycerol.
Description: A Mouse monoclonal antibody against Human Interleukin 8 (IL8)

Interleukin 8 (IL8) Monoclonal Antibody (Human)

4-MAA080Hu24
  • EUR 221.00
  • EUR 2114.00
  • EUR 535.00
  • EUR 274.00
  • EUR 203.00
  • 100ul
  • 10ml
  • 1ml
  • 200ul
  • 20ul
  • Sequence of the immunogen: Ser28~Ser99
  • Buffer composition: 0.01M PBS, pH7.4, containing 0.05% Proclin-300, 50% glycerol.
Description: A Mouse monoclonal antibody against Human Interleukin 8 (IL8)

Interleukin 8 (IL8) Monoclonal Antibody (Pig)

4-MAA080Po22
  • EUR 249.00
  • EUR 2549.00
  • EUR 634.00
  • EUR 313.00
  • EUR 215.00
  • 100ul
  • 10ml
  • 1ml
  • 200ul
  • 20ul
  • Sequence of the immunogen: Ala26~Gln103
  • Buffer composition: PBS, pH7.4, containing 0.02% NaN3, 50% glycerol.
Description: A Mouse monoclonal antibody against Pig Interleukin 8 (IL8)

Interleukin 8 (IL8) Monoclonal Antibody (Pig)

4-MAA080Po24
  • EUR 249.00
  • EUR 2549.00
  • EUR 634.00
  • EUR 313.00
  • EUR 215.00
  • 100ul
  • 10ml
  • 1ml
  • 200ul
  • 20ul
  • Sequence of the immunogen: Ala26~Gln103
  • Buffer composition: PBS, pH7.4, containing 0.02% NaN3, 50% glycerol.
Description: A Mouse monoclonal antibody against Pig Interleukin 8 (IL8)

Interleukin 8 (IL8) Monoclonal Antibody (Pig)

4-MAA080Po26
  • EUR 249.00
  • EUR 2549.00
  • EUR 634.00
  • EUR 313.00
  • EUR 215.00
  • 100ul
  • 10ml
  • 1ml
  • 200ul
  • 20ul
  • Sequence of the immunogen: Ala26~Gln103
  • Buffer composition: PBS, pH7.4, containing 0.02% NaN3, 50% glycerol.
Description: A Mouse monoclonal antibody against Pig Interleukin 8 (IL8)

Interleukin 8 (IL8) Monoclonal Antibody (Rabbit)

4-MAA080Rb22
  • EUR 251.00
  • EUR 2589.00
  • EUR 643.00
  • EUR 317.00
  • EUR 216.00
  • 100ul
  • 10ml
  • 1ml
  • 200ul
  • 20ul
  • Sequence of the immunogen: Ala23~Ser101
  • Buffer composition: 0.01M PBS, pH7.4, containing 0.05% Proclin-300, 50% glycerol.
Description: A Mouse monoclonal antibody against Rabbit Interleukin 8 (IL8)

Guinea pig Interleukin 8 (IL8) ELISA Kit

DLR-IL8-Gu-48T 48T
EUR 388
  • Should the Guinea pig Interleukin 8 (IL8) ELISA Kit is proven to show malperformance, you will receive a refund or a free replacement.
Description: A sandwich quantitative ELISA assay kit for detection of Guinea pig Interleukin 8 (IL8) in samples from serum, plasma, tissue homogenates, cell lysates, cell culture supernates or other biological fluids.

Guinea pig Interleukin 8 (IL8) ELISA Kit

DLR-IL8-Gu-96T 96T
EUR 496
  • Should the Guinea pig Interleukin 8 (IL8) ELISA Kit is proven to show malperformance, you will receive a refund or a free replacement.
Description: A sandwich quantitative ELISA assay kit for detection of Guinea pig Interleukin 8 (IL8) in samples from serum, plasma, tissue homogenates, cell lysates, cell culture supernates or other biological fluids.

Guinea pig Interleukin 8 (IL8) ELISA Kit

RDR-IL8-Gu-48Tests 48 Tests
EUR 391

Guinea pig Interleukin 8 (IL8) ELISA Kit

RDR-IL8-Gu-96Tests 96 Tests
EUR 538

Guinea pig Interleukin 8 (IL8) ELISA Kit

RD-IL8-Gu-48Tests 48 Tests
EUR 375

Guinea pig Interleukin 8 (IL8) ELISA Kit

RD-IL8-Gu-96Tests 96 Tests
EUR 515

Interleukin 8 (IL8) Antibody

20-abx009111
  • EUR 300.00
  • EUR 439.00
  • EUR 189.00
  • 100 ul
  • 200 ul
  • 30 ul
  • Shipped within 5-10 working days.

Interleukin 8 (IL8) Antibody

abx018002-100ug 100 ug
EUR 342
  • Shipped within 5-10 working days.

Interleukin 8 (IL8) Antibody

abx020956-05mg 0.5 mg
EUR 1080
  • Shipped within 5-10 working days.

Interleukin 8 (IL8) Antibody

abx216289-100ug 100 ug
EUR 439
  • Shipped within 5-10 working days.

Interleukin 8 (IL8) Antibody

20-abx177199
  • EUR 356.00
  • EUR 133.00
  • EUR 1038.00
  • EUR 523.00
  • EUR 300.00
  • 100 ug
  • 10 ug
  • 1 mg
  • 200 ug
  • 50 ug
  • Shipped within 5-12 working days.

Interleukin 8 (IL8) Antibody

20-abx177201
  • EUR 1191.00
  • EUR 578.00
  • 1 mg
  • 200 ug
  • Please enquire.

Interleukin 8 (IL8) Antibody

20-abx100960
  • EUR 314.00
  • EUR 133.00
  • EUR 829.00
  • EUR 425.00
  • EUR 272.00
  • 100 ug
  • 10 ug
  • 1 mg
  • 200 ug
  • 50 ug
  • Shipped within 5-12 working days.

Interleukin 8 (IL8) Antibody

20-abx100961
  • EUR 411.00
  • EUR 133.00
  • EUR 1121.00
  • EUR 551.00
  • EUR 314.00
  • 100 ug
  • 10 ug
  • 1 mg
  • 200 ug
  • 50 ug
  • Shipped within 5-7 working days.

Interleukin 8 (IL8) Antibody

20-abx100962
  • EUR 411.00
  • EUR 133.00
  • EUR 1121.00
  • EUR 551.00
  • EUR 314.00
  • 100 ug
  • 10 ug
  • 1 mg
  • 200 ug
  • 50 ug
  • Shipped within 5-12 working days.

Interleukin 8 (IL8) Antibody

20-abx100963
  • EUR 300.00
  • EUR 704.00
  • EUR 356.00
  • EUR 154.00
  • EUR 244.00
  • 100 ug
  • 1 mg
  • 200 ug
  • 20 ug
  • 50 ug
  • Shipped within 5-7 working days.

Interleukin 8 (IL8) Antibody

20-abx100964
  • EUR 300.00
  • EUR 704.00
  • EUR 356.00
  • EUR 154.00
  • EUR 244.00
  • 100 ug
  • 1 mg
  • 200 ug
  • 20 ug
  • 50 ug
  • Shipped within 5-7 working days.

Interleukin 8 (IL8) Antibody

20-abx100965
  • EUR 398.00
  • EUR 133.00
  • EUR 1066.00
  • EUR 523.00
  • EUR 300.00
  • 100 ug
  • 10 ug
  • 1 mg
  • 200 ug
  • 50 ug
  • Shipped within 5-12 working days.

Interleukin 8 (IL8) Antibody

20-abx100966
  • EUR 314.00
  • EUR 773.00
  • EUR 411.00
  • EUR 154.00
  • EUR 258.00
  • 100 ug
  • 1 mg
  • 200 ug
  • 20 ug
  • 50 ug
  • Shipped within 5-7 working days.

Interleukin 8 (IL8) Antibody

20-abx100967
  • EUR 411.00
  • EUR 133.00
  • EUR 1163.00
  • EUR 565.00
  • EUR 314.00
  • 100 ug
  • 10 ug
  • 1 mg
  • 200 ug
  • 50 ug
  • Shipped within 5-12 working days.

Interleukin 8 (IL8) Antibody

20-abx100969
  • EUR 439.00
  • EUR 133.00
  • EUR 1233.00
  • EUR 592.00
  • EUR 328.00
  • 100 ug
  • 10 ug
  • 1 mg
  • 200 ug
  • 50 ug
  • Shipped within 5-12 working days.

Interleukin 8 (IL8) Antibody

20-abx100970
  • EUR 342.00
  • EUR 871.00
  • EUR 453.00
  • EUR 154.00
  • EUR 272.00
  • 100 ug
  • 1 mg
  • 200 ug
  • 20 ug
  • 50 ug
  • Shipped within 5-15 working days.

Interleukin 8 (IL8) Antibody

20-abx100971
  • EUR 453.00
  • EUR 133.00
  • EUR 1316.00
  • EUR 634.00
  • EUR 342.00
  • 100 ug
  • 10 ug
  • 1 mg
  • 200 ug
  • 50 ug
  • Shipped within 5-7 working days.

Interleukin 8 (IL8) Antibody

20-abx100972
  • EUR 467.00
  • EUR 133.00
  • EUR 1372.00
  • EUR 648.00
  • EUR 356.00
  • 100 ug
  • 10 ug
  • 1 mg
  • 200 ug
  • 50 ug
  • Shipped within 5-7 working days.

Interleukin 8 (IL8) Antibody

abx036426-100ug 100 ug
EUR 391
  • Shipped within 5-10 working days.

Interleukin 8 (IL8) Antibody

20-abx131832
  • EUR 356.00
  • EUR 926.00
  • EUR 467.00
  • EUR 154.00
  • EUR 272.00
  • 100 ug
  • 1 mg
  • 200 ug
  • 20 ug
  • 50 ug
  • Shipped within 5-7 working days.

Interleukin 8 (IL8) Antibody

20-abx131833
  • EUR 342.00
  • EUR 871.00
  • EUR 453.00
  • EUR 154.00
  • EUR 272.00
  • 100 ug
  • 1 mg
  • 200 ug
  • 20 ug
  • 50 ug
  • Shipped within 5-7 working days.

Interleukin 8 (IL8) Antibody

20-abx131834
  • EUR 328.00
  • EUR 829.00
  • EUR 425.00
  • EUR 154.00
  • EUR 258.00
  • 100 ug
  • 1 mg
  • 200 ug
  • 20 ug
  • 50 ug
  • Shipped within 5-7 working days.

Interleukin 8 (IL8) Antibody

20-abx131835
  • EUR 328.00
  • EUR 843.00
  • EUR 439.00
  • EUR 154.00
  • EUR 258.00
  • 100 ug
  • 1 mg
  • 200 ug
  • 20 ug
  • 50 ug
  • Shipped within 5-7 working days.

Interleukin 8 (IL8) Antibody

20-abx131836
  • EUR 342.00
  • EUR 871.00
  • EUR 453.00
  • EUR 154.00
  • EUR 272.00
  • 100 ug
  • 1 mg
  • 200 ug
  • 20 ug
  • 50 ug
  • Shipped within 5-7 working days.

Interleukin 8 (IL8) Antibody

20-abx131837
  • EUR 342.00
  • EUR 871.00
  • EUR 453.00
  • EUR 154.00
  • EUR 272.00
  • 100 ug
  • 1 mg
  • 200 ug
  • 20 ug
  • 50 ug
  • Shipped within 5-7 working days.

Interleukin 8 (IL8) Antibody

20-abx131838
  • EUR 300.00
  • EUR 704.00
  • EUR 356.00
  • EUR 154.00
  • EUR 244.00
  • 100 ug
  • 1 mg
  • 200 ug
  • 20 ug
  • 50 ug
  • Shipped within 5-7 working days.

Interleukin 8 (IL8) Antibody

20-abx131839
  • EUR 328.00
  • EUR 829.00
  • EUR 425.00
  • EUR 154.00
  • EUR 258.00
  • 100 ug
  • 1 mg
  • 200 ug
  • 20 ug
  • 50 ug
  • Shipped within 5-7 working days.

Interleukin 8 (IL8) Antibody

20-abx131840
  • EUR 328.00
  • EUR 829.00
  • EUR 425.00
  • EUR 154.00
  • EUR 258.00
  • 100 ug
  • 1 mg
  • 200 ug
  • 20 ug
  • 50 ug
  • Shipped within 5-7 working days.

Interleukin 8 (IL8) Antibody

20-abx137023
  • EUR 356.00
  • EUR 523.00
  • 0.5 mg
  • 1 mg
  • Shipped within 5-10 working days.

Interleukin 8 (IL8) Antibody

20-abx173191
  • EUR 356.00
  • EUR 913.00
  • EUR 467.00
  • EUR 154.00
  • EUR 272.00
  • 100 ug
  • 1 mg
  • 200 ug
  • 20 ug
  • 50 ug
  • Shipped within 5-12 working days.

Interleukin 8 (IL8) Antibody

20-abx270103
  • EUR 467.00
  • EUR 537.00
  • EUR 272.00
  • EUR 815.00
  • EUR 356.00
  • 100 tests
  • 200 tests
  • 25 tests
  • 500 tests
  • 50 tests
  • Shipped within 5-15 working days.

Interleukin 8 (IL8) Antibody

20-abx270152
  • EUR 467.00
  • EUR 537.00
  • EUR 272.00
  • EUR 815.00
  • EUR 356.00
  • 100 tests
  • 200 tests
  • 25 tests
  • 500 tests
  • 50 tests
  • Shipped within 5-15 working days.

Interleukin 8 (IL8) Antibody

20-abx270200
  • EUR 467.00
  • EUR 537.00
  • EUR 272.00
  • EUR 815.00
  • EUR 356.00
  • 100 tests
  • 200 tests
  • 25 tests
  • 500 tests
  • 50 tests
  • Shipped within 5-15 working days.

Interleukin 8 (IL8) Antibody

20-abx270201
  • EUR 467.00
  • EUR 537.00
  • EUR 272.00
  • EUR 815.00
  • EUR 356.00
  • 100 tests
  • 200 tests
  • 25 tests
  • 500 tests
  • 50 tests
  • Shipped within 5-15 working days.

MET un RON receptoru tirozīna kināzes kolorektālajā adenokarcinomā: molekulāras iespējas kā zāļu mērķi un antivielu un zāļu konjugāti ārstēšanai

Augstākā kolorektālā adenokarcinoma (CRAC), ko raksturo atšķirīgs histopatoloģisks izskats, tālu orgānu metastāzes, iegūta ķīmijrezistence un audzēja ģenētiskais stublājs, ir daudz neviendabīgu vēžu ar atšķirīgiem ģenētiskiem parakstiem un ļaundabīgiem fenotipiem. CRAC terapija onkologiem ir biedējoša darbība.

Šobrīd cīņā pret šo letālo slimību ir izmantotas daudzas metodes kopā ar molekulāro koncentrēšanos uz terapeitisko monoklonālo antivielu, mazmolekulāro kināzes inhibitoru un imūnregulācijas kontrolpunkta līdzekli. Tomēr šīs terapeitiskās metodes un pieejas gūst tikai ierobežotus panākumus. Tādējādi farmaceitiski vēlas atrast jaunus mērķus un izstrādāt jaunus CRAC līdzekļa terapijas līdzekļus. MET un RON receptoru tirozīna kināzes ir iesaistītas CRAC patoģenēzē.

Zinātniskie pētījumi ir atklājuši, ka novirzīta MET un / vai RON ekspresija un signalizācija ir būtiska, regulējot CRAC attīstību un ļaundabīgos fenotipus. Paaugstinātai MET un / vai RON izteiksmei ir arī CRAC attīstības un skartās personas izdzīvošanas prognozes vērtība.

Šīs iespējas piedāvā loģisko pamatu koncentrēties uz TER un RON zinātniskai CRAC iejaukšanai. Pašlaik, izmantojot mazmolekulārās kināzes inhibitorus, koncentrējoties uz MET CRAC terapijai, ir panākts būtisks progress, saņemot vairākus apstiprinājumus zinātniskai lietošanai.

Neskatoties uz to, uz antivielām balstītie bioterapeitiskie līdzekļi, lai arī zinātniski pētījumi veikti vairāk nekā astoņus gadus, ir guvuši nelielu progresu vai nav devuši nekādu progresu. Šajā novērtējumā mēs koncentrējamies uz MET un / vai RON nozīmi CRAC audzēja veidošanā un anti-MET, anti-RON un MET un RON-dual augšanu, koncentrējoties uz antivielu un zāļu konjugātiem zinātniskai lietderībai. Katra preklīniskā un zinātniskā pētījuma secinājumi agrāk vai vēlāk atklāj šī jaunā veida bioterapeitisko līdzekļu potenciālu CRAC ārstēšanai.

Seruma anti-Neu5Gc antivielu afinitātes attīrīšana atklāja paaugstinātu diapazonu un neobjektīvus masīvu repertuāra modeļus cilvēkiem, kuriem palielinājās Neu5Gc diapazons, bez antivielu afinitātes palielināšanās. Turklāt augsta gaļas svara samazināšanas plānā antivielu daudzveidības modeļi uz glikāna mikroelementiem mainījās ar Neu5Gcα3 saistīto glikānu virzienā, paaugstinot α3 / α6-glikānu attiecību.

Secinājumi: Mēs atklājām pārredzamu hipersaiti starp grādiem un seruma anti-Neu5Gc IgG un Neu5Gc patēriņu no rozā gaļas un piena produktiem. Šīs precīzās racionālās metodikas ļāva izstrādāt Gcemicindeksu, lai vienkāršotu Neu5Gc novērtēšanu ēdienreizēs, kas, bez šaubām, būtu pielāgots uztura ieteikumiem, lai samazinātu lielāko daļu vēža risku.

Antivielu reakcija uz suņu parvovīrusa vakcināciju suņiem ar hiperadrenokortikismu, kas tiek ārstēta ar Trilostane

  • Nav zināms, kā suņi ar hiperadrenokortikismu (HAC) reaģē uz vakcināciju. Šajā pētījumā tika izmērītas antivielas pretstatā suņu parvovīrusam (CPV) suņiem ar HAC, kas ar trilostānu apstrādāts agrāk un pēc CPV vakcinācijas, un atšķirībā no imūnās atbildes reakcijas uz veselīgu suņu reakciju. 
  • Vienpadsmit ilkņi ar HAC un pilnvērtīgi vecumam atbilstoši suņi (n = 31) ieguva modificētu dzīvo CPV vakcīnu. Antivielas ir izlemtas 0., 7. un 28. dienā ar hemaglutinācijas inhibīciju. Lai saskaņotu suņu imūnreakciju ar HAC un pilnvērtīgiem ilkņiem, tika izmantots vienveidīgais novērtējums.
  • Pirmsvakcinācijas antivielas (≥10) ir atklātas 100% suņu ar HAC (11/11; 95% TI: 70,0-100) un 93,5% pilnvērtīgu suņu (29/31; 95% TI: 78,3- 99.2). Suņiem ar HAC netika novērota ≥Four reizes lielāka antivielu titra palielināšanās, turpretī 22,6% pilnvērtīgu ilkņu gadījumā ≥Four reizes titra palielināšanās tika novērota (7/31; 95% TI: 11,1-40,1).
  • Maigi ar vakcīnu saistīti antagonistiski gadījumi (VAAE) ir konstatēti 54,5% suņu ar HAC (6/11; 95% TI: 28,0-78,8) un 29,0% pilnvērtīgu ilkņu (9/31; 95% TI: 15,9) -46,8). Nebija būtiskas atšķirības pirmsvakcinācijas antivielu klātbūtnē (p = 1.000), atbildes reakcija uz vakcināciju (p = 0.161), kā arī VAAE izplatības ziņā (p = 0.158). Imūnsistēmas suņu darbība ar HAC, kas apstrādāta ar trilostānu, šķiet līdzīga veselīgu ilkņu darbībai.

Linkeru izstrāde un validācija vietņu specifiskai antivielu-narkotiku konjugātu sagatavošanai, kas satur vairākas zāļu kopijas vienā cisteīna konjugācijas vietnē

Pirmās paaudzes cisteīna bāzes specifisko antivielu un zāļu konjugāti (ADC) ir ierobežoti līdz 1 narkotikai uz vienu cisteīnu. Neskatoties uz to, noteiktiem mērķiem nepieciešama pārmērīga zāļu un antivielu attiecība (DAR), kas atbilst zemas jaudas kravām. Palielinātu zāļu slodzi var panākt, izmantojot klasiskās cisteīna konjugācijas stratēģijas, tomēr tās noved pie neviendabīguma, neoptimālas efektivitātes un farmakokinētikas.

Šeit mēs aprakstām to heterobifunkcionālo saišu dizainu, sintēzi un apstiprināšanu, kuras var izmantot ADC ar divu, trīs un Four DAR sagatavošanai, katrai vietnei raksturīgā metodē vienā cisteīna konjugācijas vietnē, kas noved pie vietnei specifiskiem ADC ar DAR 4, seši un astoņi. Izstrādātie saites satur sulfhidrilam raksturīgu jodoacetilreaktīvu grupu un vairākas cikliskas diēna daļas, kas, izmantojot Dīla-Aldera reakciju, varētu efektīvi reaģēt ar lietderīgo slodzi ar maleimīdu nesošajām kravām.

 Kā idejas pierādījumu mēs sintezējām vietnei specifiskus DAR 4, sešus un astoņus ADC, kas satur tubulizīnu (AZ13601508), izmantojot inženierijas antivielas ar cisteīnu, kas ievietots aiz 239. vietas antivielu CH2 zonā.

Mēs novērtējām un atšķirībā no tā ADC in vitro citotoksicitāti, kas iegūta, izmantojot šeit aprakstīto vietnei specifisko platformu, ar ADC, kas gatavi izmantot klasisko cisteīna konjugāciju. Mūsu zināšanas apstiprināja jaunu konjugācijas platformu, kuras pamatā ir cisteīns, vietnei specifisku ADC sagatavošanai ar pārmērīgu zāļu slodzi terapeitiskos nolūkos.

 

Mouse Protectin (CD59) ELISA Kit

DLR-CD59-Mu-96T 96T
EUR 661
  • Should the Mouse Protectin (CD59) ELISA Kit is proven to show malperformance, you will receive a refund or a free replacement.
Description: A sandwich quantitative ELISA assay kit for detection of Mouse Protectin (CD59) in samples from serum, plasma, urine or other biological fluids.

Mouse Protectin (CD59) ELISA Kit

RDR-CD59-Mu-48Tests 48 Tests
EUR 534

Mouse Protectin (CD59) ELISA Kit

RDR-CD59-Mu-96Tests 96 Tests
EUR 742

Mouse Protectin (CD59) ELISA Kit

RD-CD59-Mu-48Tests 48 Tests
EUR 511

Mouse Protectin (CD59) ELISA Kit

RD-CD59-Mu-96Tests 96 Tests
EUR 709

Human Protectin (CD59) ELISA Kit

DLR-CD59-Hu-48T 48T
EUR 498
  • Should the Human Protectin (CD59) ELISA Kit is proven to show malperformance, you will receive a refund or a free replacement.
Description: A sandwich quantitative ELISA assay kit for detection of Human Protectin (CD59) in samples from serum, plasma, cell lysates or other biological fluids.

Human Protectin (CD59) ELISA Kit

DLR-CD59-Hu-96T 96T
EUR 647
  • Should the Human Protectin (CD59) ELISA Kit is proven to show malperformance, you will receive a refund or a free replacement.
Description: A sandwich quantitative ELISA assay kit for detection of Human Protectin (CD59) in samples from serum, plasma, cell lysates or other biological fluids.

Human Protectin (CD59) ELISA Kit

RDR-CD59-Hu-48Tests 48 Tests
EUR 522

Human Protectin (CD59) ELISA Kit

RDR-CD59-Hu-96Tests 96 Tests
EUR 724

Human Protectin (CD59) ELISA Kit

RD-CD59-Hu-48Tests 48 Tests
EUR 500

Human Protectin (CD59) ELISA Kit

RD-CD59-Hu-96Tests 96 Tests
EUR 692

Mouse Monoclonal Anti-Human CD59, (Biotin) (Clone 1F5) (mouse IgG1)

CD59-B 25 tests
EUR 408

Mouse Monoclonal Anti-Human CD59, (FITC) (Clone 1F5) (mouse IgG1)

CD59-F 25 tests
EUR 408

Mouse Monoclonal Anti-Human CD59, (PE) (Clone 1F5) (mouse IgG1)

CD59-PE 25 tests
EUR 408

Protectin (CD59) Monoclonal Antibody (Rabbit)

4-MAB336Rb21
  • EUR 251.00
  • EUR 2589.00
  • EUR 643.00
  • EUR 317.00
  • EUR 216.00
  • 100ul
  • 10ml
  • 1ml
  • 200ul
  • 20ul
  • Sequence of the immunogen: Ser25~Leu104
  • Buffer composition: 0.01M PBS, pH7.4, containing 0.05% Proclin-300, 50% glycerol.
Description: A Mouse monoclonal antibody against Rabbit Protectin (CD59)

Protectin (CD59) Antibody

abx021467-100ug 100 ug
EUR 453
  • Shipped within 5-10 working days.

Protectin (CD59) Antibody

20-abx178138
  • EUR 425.00
  • EUR 133.00
  • EUR 1177.00
  • EUR 578.00
  • EUR 328.00
  • 100 ug
  • 10 ug
  • 1 mg
  • 200 ug
  • 50 ug
  • Shipped within 5-12 working days.

Protectin (CD59) Antibody

abx200391-100ug 100 ug
EUR 328
  • Shipped within 2-3 weeks.

Protectin (CD59) Antibody

20-abx210170
  • EUR 439.00
  • EUR 328.00
  • 100 ug
  • 50 ug
  • Shipped within 5-10 working days.

Protectin (CD59) Antibody

20-abx210424
  • EUR 411.00
  • EUR 300.00
  • 100 ul
  • 50 ul
  • Shipped within 5-10 working days.

Protectin (CD59) Antibody

20-abx100397
  • EUR 411.00
  • EUR 133.00
  • EUR 1149.00
  • EUR 565.00
  • EUR 314.00
  • 100 ug
  • 10 ug
  • 1 mg
  • 200 ug
  • 50 ug
  • Shipped within 5-12 working days.

Protectin (CD59) Antibody

20-abx100398
  • EUR 425.00
  • EUR 133.00
  • EUR 1177.00
  • EUR 578.00
  • EUR 328.00
  • 100 ug
  • 10 ug
  • 1 mg
  • 200 ug
  • 50 ug
  • Shipped within 5-7 working days.

Protectin (CD59) Antibody

20-abx100399
  • EUR 439.00
  • EUR 133.00
  • EUR 1247.00
  • EUR 592.00
  • EUR 328.00
  • 100 ug
  • 10 ug
  • 1 mg
  • 200 ug
  • 50 ug
  • Shipped within 5-12 working days.

Protectin (CD59) Antibody

20-abx100400
  • EUR 439.00
  • EUR 133.00
  • EUR 1247.00
  • EUR 592.00
  • EUR 328.00
  • 100 ug
  • 10 ug
  • 1 mg
  • 200 ug
  • 50 ug
  • Shipped within 5-12 working days.

Protectin (CD59) Antibody

20-abx100401
  • EUR 467.00
  • EUR 133.00
  • EUR 1344.00
  • EUR 634.00
  • EUR 356.00
  • 100 ug
  • 10 ug
  • 1 mg
  • 200 ug
  • 50 ug
  • Shipped within 5-7 working days.

Protectin (CD59) Antibody

20-abx100402
  • EUR 481.00
  • EUR 133.00
  • EUR 1442.00
  • EUR 676.00
  • EUR 356.00
  • 100 ug
  • 10 ug
  • 1 mg
  • 200 ug
  • 50 ug
  • Shipped within 5-12 working days.

Protectin (CD59) Antibody

20-abx111491
  • EUR 732.00
  • EUR 398.00
  • 150 ul
  • 50 ul
  • Shipped within 5-10 working days.

Protectin (CD59) Antibody

abx036096-100ug 100 ug
EUR 391
  • Shipped within 5-10 working days.

Protectin (CD59) Antibody

20-abx132385
  • EUR 328.00
  • EUR 843.00
  • EUR 439.00
  • EUR 154.00
  • EUR 258.00
  • 100 ug
  • 1 mg
  • 200 ug
  • 20 ug
  • 50 ug
  • Shipped within 5-7 working days.

Protectin (CD59) Antibody

20-abx109633
  • EUR 411.00
  • EUR 1845.00
  • EUR 599.00
  • EUR 182.00
  • EUR 300.00
  • 100 ug
  • 1 mg
  • 200 ug
  • 20 ug
  • 50 ug
  • Shipped within 5-10 working days.

Protectin (CD59) Antibody

20-abx109634
  • EUR 411.00
  • EUR 1845.00
  • EUR 599.00
  • EUR 182.00
  • EUR 300.00
  • 100 ug
  • 1 mg
  • 200 ug
  • 20 ug
  • 50 ug
  • Shipped within 5-10 working days.

Protectin (CD59) Antibody

abx139305-01mg 0.1 mg
EUR 356
  • Shipped within 5-12 working days.

Protectin (CD59) Antibody

abx139306-01mg 0.1 mg
EUR 370
  • Shipped within 5-12 working days.

Protectin (CD59) Antibody

abx139307-01mg 0.1 mg
EUR 356
  • Shipped within 5-12 working days.

Protectin (CD59) Antibody

20-abx174238
  • EUR 815.00
  • EUR 425.00
  • 1 mg
  • 200 ug
  • Please enquire.

Protectin (CD59) Antibody

abx011952-100ug 100 ug
EUR 411
  • Shipped within 5-10 working days.

Protectin (CD59) Antibody

20-abx270064
  • EUR 467.00
  • EUR 537.00
  • EUR 272.00
  • EUR 815.00
  • EUR 356.00
  • 100 tests
  • 200 tests
  • 25 tests
  • 500 tests
  • 50 tests
  • Shipped within 5-12 working days.

Protectin (CD59) Antibody

20-abx339758
  • EUR 411.00
  • EUR 300.00
  • 100 ul
  • 50 ul
  • Shipped within 5-10 working days.

Protectin (CD59) Antibody

20-abx323672
  • EUR 314.00
  • EUR 244.00
  • 100 ug
  • 50 ug
  • Shipped within 5-10 working days.

Protectin (CD59) Antibody

20-abx225094
  • EUR 370.00
  • EUR 606.00
  • EUR 314.00
  • 100 ul
  • 200 ul
  • 50 ul
  • Shipped within 5-10 working days.

Protectin (CD59) Antibody

abx231489-100ug 100 ug
EUR 481
  • Shipped within 5-12 working days.

Protectin (CD59) Antibody

20-abx001417
  • EUR 411.00
  • EUR 592.00
  • EUR 314.00
  • 100 ul
  • 200 ul
  • 50 ul
  • Shipped within 5-10 working days.

Anti-CD59 / Complement Regulatory Protein / Protectin Monoclonal Antibody

M00914 100ug/vial
EUR 397
Description: Mouse Monoclonal CD59 / Complement Regulatory Protein / Protectin Antibody. Validated in IF, IHC and tested in Human.

Protectin (CD59) Monoclonal Antibody (Rabbit), APC

4-MAB336Rb21-APC
  • EUR 352.00
  • EUR 3383.00
  • EUR 939.00
  • EUR 450.00
  • EUR 223.00
  • 100ul
  • 10ml
  • 1ml
  • 200ul
  • 20ul
  • Sequence of the immunogen: Ser25~Leu104
  • Buffer composition: 0.01M PBS, pH7.4, containing 0.05% Proclin-300, 50% glycerol.
Description: A Mouse monoclonal antibody against Rabbit Protectin (CD59). This antibody is labeled with APC.

Protectin (CD59) Monoclonal Antibody (Rabbit), Biotinylated

4-MAB336Rb21-Biotin
  • EUR 316.00
  • EUR 2539.00
  • EUR 747.00
  • EUR 388.00
  • EUR 221.00
  • 100ul
  • 10ml
  • 1ml
  • 200ul
  • 20ul
  • Sequence of the immunogen: Ser25~Leu104
  • Buffer composition: 0.01M PBS, pH7.4, containing 0.05% Proclin-300, 50% glycerol.
Description: A Mouse monoclonal antibody against Rabbit Protectin (CD59). This antibody is labeled with Biotin.

Protectin (CD59) Monoclonal Antibody (Rabbit), Cy3

4-MAB336Rb21-Cy3
  • EUR 428.00
  • EUR 4469.00
  • EUR 1211.00
  • EUR 559.00
  • EUR 255.00
  • 100ul
  • 10ml
  • 1ml
  • 200ul
  • 20ul
  • Sequence of the immunogen: Ser25~Leu104
  • Buffer composition: 0.01M PBS, pH7.4, containing 0.05% Proclin-300, 50% glycerol.
Description: A Mouse monoclonal antibody against Rabbit Protectin (CD59). This antibody is labeled with Cy3.

Protectin (CD59) Monoclonal Antibody (Rabbit), FITC

4-MAB336Rb21-FITC
  • EUR 302.00
  • EUR 2726.00
  • EUR 771.00
  • EUR 380.00
  • EUR 198.00
  • 100ul
  • 10ml
  • 1ml
  • 200ul
  • 20ul
  • Sequence of the immunogen: Ser25~Leu104
  • Buffer composition: 0.01M PBS, pH7.4, containing 0.05% Proclin-300, 50% glycerol.
Description: A Mouse monoclonal antibody against Rabbit Protectin (CD59). This antibody is labeled with FITC.

Protectin (CD59) Monoclonal Antibody (Rabbit), HRP

4-MAB336Rb21-HRP
  • EUR 322.00
  • EUR 2948.00
  • EUR 830.00
  • EUR 407.00
  • EUR 210.00
  • 100ul
  • 10ml
  • 1ml
  • 200ul
  • 20ul
  • Sequence of the immunogen: Ser25~Leu104
  • Buffer composition: 0.01M PBS, pH7.4, containing 0.05% Proclin-300, 50% glycerol.
Description: A Mouse monoclonal antibody against Rabbit Protectin (CD59). This antibody is labeled with HRP.

Protectin (CD59) Monoclonal Antibody (Rabbit), PE

4-MAB336Rb21-PE
  • EUR 302.00
  • EUR 2726.00
  • EUR 771.00
  • EUR 380.00
  • EUR 198.00
  • 100ul
  • 10ml
  • 1ml
  • 200ul
  • 20ul
  • Sequence of the immunogen: Ser25~Leu104
  • Buffer composition: 0.01M PBS, pH7.4, containing 0.05% Proclin-300, 50% glycerol.
Description: A Mouse monoclonal antibody against Rabbit Protectin (CD59). This antibody is labeled with PE.

Protectin (CD59) Polyclonal Antibody (Mouse)

4-PAB336Mu01
  • EUR 243.00
  • EUR 2457.00
  • EUR 613.00
  • EUR 305.00
  • EUR 212.00
  • 100ul
  • 10ml
  • 1ml
  • 200ul
  • 20ul
  • Sequence of the immunogen: CD59 (Val22~Ser96)
  • Buffer composition: PBS, pH7.4, containing 0.02% NaN3, 50% glycerol.
Description: A Rabbit polyclonal antibody against Mouse Protectin (CD59)

Mouse Protectin (CD59) Protein

20-abx068726
  • EUR 592.00
  • EUR 258.00
  • EUR 1776.00
  • EUR 704.00
  • EUR 439.00
  • 100 ug
  • 10 ug
  • 1 mg
  • 200 ug
  • 50 ug
  • Shipped within 5-7 working days.

Protectin (CD59) Monoclonal Antibody (Rabbit), APC-Cy7

4-MAB336Rb21-APC-Cy7
  • EUR 585.00
  • EUR 6646.00
  • EUR 1759.00
  • EUR 781.00
  • EUR 326.00
  • 100ul
  • 10ml
  • 1ml
  • 200ul
  • 20ul
  • Sequence of the immunogen: Ser25~Leu104
  • Buffer composition: 0.01M PBS, pH7.4, containing 0.05% Proclin-300, 50% glycerol.
Description: A Mouse monoclonal antibody against Rabbit Protectin (CD59). This antibody is labeled with APC-Cy7.

Protectin (CD59) Antibody (PE)

abx200390-100tests 100 tests
EUR 551
  • Shipped within 3-5 working days.

Protectin (CD59) Antibody (FITC)

abx200392-100tests 100 tests
EUR 398
  • Shipped within 3-5 working days.

Protectin (CD59) Antibody (PE)

abx200393-100tests 100 tests
EUR 453
  • Shipped within 3-5 working days.

Protectin (CD59) Antibody (APC)

abx200394-100tests 100 tests
EUR 453
  • Shipped within 2-3 weeks.

Protectin (CD59) Antibody (PerCP)

abx200395-100tests 100 tests
EUR 453
  • Shipped within 2-3 weeks.

Protectin (CD59) Antibody (Biotin)

abx200396-100ug 100 ug
EUR 384
  • Shipped within 2-3 weeks.

Protectin (CD59) Antibody (Biotin)

20-abx105246
  • EUR 411.00
  • EUR 1845.00
  • EUR 599.00
  • EUR 182.00
  • EUR 300.00
  • 100 ug
  • 1 mg
  • 200 ug
  • 20 ug
  • 50 ug
  • Shipped within 5-10 working days.

Protectin (CD59) Antibody (Biotin)

20-abx105247
  • EUR 411.00
  • EUR 1845.00
  • EUR 599.00
  • EUR 182.00
  • EUR 300.00
  • 100 ug
  • 1 mg
  • 200 ug
  • 20 ug
  • 50 ug
  • Shipped within 5-10 working days.

Protectin (CD59) Antibody (FITC)

20-abx106664
  • EUR 411.00
  • EUR 1845.00
  • EUR 599.00
  • EUR 182.00
  • EUR 300.00
  • 100 ug
  • 1 mg
  • 200 ug
  • 20 ug
  • 50 ug
  • Shipped within 5-10 working days.

Protectin (CD59) Antibody (FITC)

20-abx106665
  • EUR 411.00
  • EUR 1845.00
  • EUR 599.00
  • EUR 182.00
  • EUR 300.00
  • 100 ug
  • 1 mg
  • 200 ug
  • 20 ug
  • 50 ug
  • Shipped within 5-10 working days.

Protectin (CD59) Antibody (HRP)

20-abx108081
  • EUR 411.00
  • EUR 1845.00
  • EUR 599.00
  • EUR 182.00
  • EUR 300.00
  • 100 ug
  • 1 mg
  • 200 ug
  • 20 ug
  • 50 ug
  • Shipped within 5-10 working days.

Protectin (CD59) Antibody (HRP)

20-abx108082
  • EUR 411.00
  • EUR 1845.00
  • EUR 599.00
  • EUR 182.00
  • EUR 300.00
  • 100 ug
  • 1 mg
  • 200 ug
  • 20 ug
  • 50 ug
  • Shipped within 5-10 working days.

Protectin (CD59) Antibody (FITC)

abx134463-100Assays 100 Assays
EUR 439
  • Shipped within 5-10 working days.

Protectin (CD59) Antibody (FITC)

abx134463-50Assays 50 Assays
EUR 342
  • Shipped within 5-10 working days.

Protectin (CD59) Antibody (PE)

abx139308-100tests 100 tests
EUR 481
  • Shipped within 5-12 working days.

Protectin (CD59) Antibody (APC)

abx139309-100tests 100 tests
EUR 481
  • Shipped within 5-12 working days.

Protectin (CD59) Antibody (Biotin)

abx139310-01mg 0.1 mg
EUR 425
  • Shipped within 5-12 working days.

Protectin (CD59) Antibody (FITC)

abx139311-100tests 100 tests
EUR 425
  • Shipped within 5-12 working days.

Protectin (CD59) Antibody (FITC)

20-abx270362
  • EUR 523.00
  • EUR 606.00
  • EUR 300.00
  • EUR 940.00
  • EUR 384.00
  • 100 tests
  • 200 tests
  • 25 tests
  • 500 tests
  • 50 tests
  • Shipped within 5-15 working days.

Protectin (CD59) Antibody (APC)

20-abx270594
  • EUR 704.00
  • EUR 829.00
  • EUR 370.00
  • EUR 1330.00
  • EUR 495.00
  • 100 tests
  • 200 tests
  • 25 tests
  • 500 tests
  • 50 tests
  • Shipped within 5-15 working days.

Protectin (CD59) Antibody (PE)

20-abx270826
  • EUR 606.00
  • EUR 718.00
  • EUR 328.00
  • EUR 1135.00
  • EUR 439.00
  • 100 tests
  • 200 tests
  • 25 tests
  • 500 tests
  • 50 tests
  • Shipped within 5-15 working days.

Protectin (CD59) Antibody (RPE)

abx412706-100tests 100 tests
EUR 592
  • Shipped within 1 week.

Protectin (CD59) Antibody (RPE)

abx412707-25tests025ml 25 tests (0.25 ml)
EUR 314
  • Shipped within 1 week.

Protectin (CD59) Antibody (RPE)

abx413501-100tests 100 tests
EUR 592
  • Shipped within 1 week.

Protectin (CD59) Antibody (RPE)

abx413502-25tests 25 tests
EUR 314
  • Shipped within 1 week.

Protectin (CD59) Antibody (Biotin)

20-abx272126
  • EUR 439.00
  • EUR 244.00
  • EUR 1261.00
  • EUR 606.00
  • EUR 328.00
  • 100 ug
  • 10 ug
  • 1 mg
  • 200 ug
  • 50 ug
  • Shipped within 5-12 working days.

Protectin (CD59) Antibody (Biotin)

20-abx272910
  • EUR 467.00
  • EUR 244.00
  • EUR 1344.00
  • EUR 634.00
  • EUR 342.00
  • 100 ug
  • 10 ug
  • 1 mg
  • 200 ug
  • 50 ug
  • Shipped within 5-12 working days.

Protectin (CD59) Antibody (Biotin)

20-abx273046
  • EUR 481.00
  • EUR 244.00
  • EUR 1414.00
  • EUR 662.00
  • EUR 356.00
  • 100 ug
  • 10 ug
  • 1 mg
  • 200 ug
  • 50 ug
  • Shipped within 5-15 working days.

Protectin (CD59) Antibody (Biotin)

20-abx273328
  • EUR 481.00
  • EUR 244.00
  • EUR 1414.00
  • EUR 662.00
  • EUR 356.00
  • 100 ug
  • 10 ug
  • 1 mg
  • 200 ug
  • 50 ug
  • Shipped within 5-15 working days.

Protectin (CD59) Antibody (RPE)

abx415434-100tests 100 tests
EUR 592
  • Shipped within 1 week.

Protectin (CD59) Antibody (Biotin)

20-abx273444
  • EUR 537.00
  • EUR 258.00
  • EUR 1636.00
  • EUR 759.00
  • EUR 425.00
  • 100 ug
  • 10 ug
  • 1 mg
  • 200 ug
  • 50 ug
  • Shipped within 5-15 working days.

Recombinant Protectin (CD59)

4-RPB336Hu01
  • EUR 449.44
  • EUR 223.00
  • EUR 1410.40
  • EUR 536.80
  • EUR 973.60
  • EUR 364.00
  • EUR 3376.00
  • 100 ug
  • 10ug
  • 1 mg
  • 200 ug
  • 500 ug
  • 50ug
  • 5 mg
  • Uniprot ID: P13987
  • Buffer composition: PBS, pH 7.4, containing 0.01% SKL, 1mM DTT, 5% Trehalose and Proclin300.
  • Form: Freeze-dried powder
  • Predicted Molecular Mass (KD): 14.7kDa
  • Isoelectric Point: 5.5
Description: Recombinant Human Protectin expressed in: E.coli

Recombinant Protectin (CD59)

4-RPB336Mu01
  • EUR 422.56
  • EUR 216.00
  • EUR 1309.60
  • EUR 503.20
  • EUR 906.40
  • EUR 346.00
  • EUR 3124.00
  • 100 ug
  • 10ug
  • 1 mg
  • 200 ug
  • 500 ug
  • 50ug
  • 5 mg
  • Uniprot ID: O55186
  • Buffer composition: PBS, pH 7.4, containing 0.01% SKL, 1mM DTT, 5% Trehalose and Proclin300.
  • Form: Freeze-dried powder
  • Predicted Molecular Mass (KD): 14.3kDa
  • Isoelectric Point: 5.8
Description: Recombinant Mouse Protectin expressed in: E.coli

Recombinant Protectin (CD59)

4-RPB336Po01
  • EUR 530.08
  • EUR 245.00
  • EUR 1712.80
  • EUR 637.60
  • EUR 1175.20
  • EUR 418.00
  • EUR 4132.00
  • 100 ug
  • 10ug
  • 1 mg
  • 200 ug
  • 500 ug
  • 50ug
  • 5 mg
  • Uniprot ID: O62680
  • Buffer composition: PBS, pH 7.4, containing 0.01% SKL, 1mM DTT, 5% Trehalose and Proclin300.
  • Form: Freeze-dried powder
  • Predicted Molecular Mass (KD): 12.3kDa
  • Isoelectric Point: Inquire
Description: Recombinant Pig Protectin expressed in: E.coli

Recombinant Protectin (CD59)

4-RPB336Ra01
  • EUR 413.60
  • EUR 214.00
  • EUR 1276.00
  • EUR 492.00
  • EUR 884.00
  • EUR 340.00
  • EUR 3040.00
  • 100 ug
  • 10ug
  • 1 mg
  • 200 ug
  • 500 ug
  • 50ug
  • 5 mg
  • Uniprot ID: P27274
  • Buffer composition: PBS, pH 7.4, containing 0.01% SKL, 1mM DTT, 5% Trehalose and Proclin300.
  • Form: Freeze-dried powder
  • Predicted Molecular Mass (KD): 15.0kDa
  • Isoelectric Point: Inquire
Description: Recombinant Rat Protectin expressed in: E.coli

Recombinant Protectin (CD59)

4-RPB336Rb01
  • EUR 413.60
  • EUR 214.00
  • EUR 1276.00
  • EUR 492.00
  • EUR 884.00
  • EUR 340.00
  • EUR 3040.00
  • 100 ug
  • 10ug
  • 1 mg
  • 200 ug
  • 500 ug
  • 50ug
  • 5 mg
  • Uniprot ID: O77541
  • Buffer composition: PBS, pH 7.4, containing 0.01% SKL, 1mM DTT, 5% Trehalose and Proclin300.
  • Form: Freeze-dried powder
  • Predicted Molecular Mass (KD): 14.8kDa
  • Isoelectric Point: Inquire
Description: Recombinant Rabbit Protectin expressed in: E.coli

Recombinant Protectin (CD59)

4-RPB336Si01
  • EUR 504.99
  • EUR 238.00
  • EUR 1618.72
  • EUR 606.24
  • EUR 1112.48
  • EUR 401.00
  • EUR 3896.80
  • 100 ug
  • 10ug
  • 1 mg
  • 200 ug
  • 500 ug
  • 50ug
  • 5 mg
  • Uniprot ID: Q8SQ46
  • Buffer composition: PBS, pH 7.4, containing 0.01% SKL, 1mM DTT, 5% Trehalose and Proclin300.
  • Form: Freeze-dried powder
  • Predicted Molecular Mass (KD): 15.5kDa
  • Isoelectric Point: Inquire
Description: Recombinant Simian Protectin expressed in: E.coli

Protectin (CD59) Polyclonal Antibody (Mouse), APC

4-PAB336Mu01-APC
  • EUR 340.00
  • EUR 3203.00
  • EUR 894.00
  • EUR 432.00
  • EUR 217.00
  • 100ul
  • 10ml
  • 1ml
  • 200ul
  • 20ul
  • Sequence of the immunogen: CD59 (Val22~Ser96)
  • Buffer composition: PBS, pH7.4, containing 0.02% NaN3, 50% glycerol.
Description: A Rabbit polyclonal antibody against Mouse Protectin (CD59). This antibody is labeled with APC.

Protectin (CD59) Polyclonal Antibody (Mouse), Biotinylated

4-PAB336Mu01-Biotin
  • EUR 307.00
  • EUR 2407.00
  • EUR 714.00
  • EUR 375.00
  • EUR 217.00
  • 100ul
  • 10ml
  • 1ml
  • 200ul
  • 20ul
  • Sequence of the immunogen: CD59 (Val22~Ser96)
  • Buffer composition: PBS, pH7.4, containing 0.02% NaN3, 50% glycerol.
Description: A Rabbit polyclonal antibody against Mouse Protectin (CD59). This antibody is labeled with Biotin.

Protectin (CD59) Polyclonal Antibody (Mouse), Cy3

4-PAB336Mu01-Cy3
  • EUR 411.00
  • EUR 4229.00
  • EUR 1151.00
  • EUR 535.00
  • EUR 248.00
  • 100ul
  • 10ml
  • 1ml
  • 200ul
  • 20ul
  • Sequence of the immunogen: CD59 (Val22~Ser96)
  • Buffer composition: PBS, pH7.4, containing 0.02% NaN3, 50% glycerol.
Description: A Rabbit polyclonal antibody against Mouse Protectin (CD59). This antibody is labeled with Cy3.

Protectin (CD59) Polyclonal Antibody (Mouse), FITC

4-PAB336Mu01-FITC
  • EUR 292.00
  • EUR 2582.00
  • EUR 735.00
  • EUR 366.00
  • EUR 194.00
  • 100ul
  • 10ml
  • 1ml
  • 200ul
  • 20ul
  • Sequence of the immunogen: CD59 (Val22~Ser96)
  • Buffer composition: PBS, pH7.4, containing 0.02% NaN3, 50% glycerol.
Description: A Rabbit polyclonal antibody against Mouse Protectin (CD59). This antibody is labeled with FITC.

Protectin (CD59) Polyclonal Antibody (Mouse), HRP

4-PAB336Mu01-HRP
  • EUR 311.00
  • EUR 2792.00
  • EUR 791.00
  • EUR 391.00
  • EUR 205.00
  • 100ul
  • 10ml
  • 1ml
  • 200ul
  • 20ul
  • Sequence of the immunogen: CD59 (Val22~Ser96)
  • Buffer composition: PBS, pH7.4, containing 0.02% NaN3, 50% glycerol.
Description: A Rabbit polyclonal antibody against Mouse Protectin (CD59). This antibody is labeled with HRP.

Protectin (CD59) Polyclonal Antibody (Mouse), PE

4-PAB336Mu01-PE
  • EUR 292.00
  • EUR 2582.00
  • EUR 735.00
  • EUR 366.00
  • EUR 194.00
  • 100ul
  • 10ml
  • 1ml
  • 200ul
  • 20ul
  • Sequence of the immunogen: CD59 (Val22~Ser96)
  • Buffer composition: PBS, pH7.4, containing 0.02% NaN3, 50% glycerol.
Description: A Rabbit polyclonal antibody against Mouse Protectin (CD59). This antibody is labeled with PE.

Mouse Protectin (CD59) CLIA Kit

20-abx492660
  • EUR 8569.00
  • EUR 4560.00
  • EUR 1052.00
  • 10 × 96 tests
  • 5 × 96 tests
  • 96 tests
  • Please enquire.

Mouse Protectin (CD59) ELISA Kit

SEB336Mu-10x96wellstestplate 10x96-wells test plate
EUR 4626.78
  • The Intra-assay Precision is determined when 3 samples with low, middle and high level of Mouse Protectin (CD59) were tested on 3 different plates, 8 replicates in each plate
  • CV(%) = SD/meanX100
  • Intra-Assay: CV<10%
  • Inter-Assay: CV<12%
Description: This is Double-antibody Sandwich Enzyme-linked immunosorbent assay for detection of Mouse Protectin (CD59) in serum, plasma, urine and other biological fluids.

Mouse Protectin (CD59) ELISA Kit

SEB336Mu-1x48wellstestplate 1x48-wells test plate
EUR 468.68
  • The Intra-assay Precision is determined when 3 samples with low, middle and high level of Mouse Protectin (CD59) were tested on 3 different plates, 8 replicates in each plate
  • CV(%) = SD/meanX100
  • Intra-Assay: CV<10%
  • Inter-Assay: CV<12%
Description: This is Double-antibody Sandwich Enzyme-linked immunosorbent assay for detection of Mouse Protectin (CD59) in serum, plasma, urine and other biological fluids.

Mouse Protectin (CD59) ELISA Kit

SEB336Mu-1x96wellstestplate 1x96-wells test plate
EUR 626.68
  • The Intra-assay Precision is determined when 3 samples with low, middle and high level of Mouse Protectin (CD59) were tested on 3 different plates, 8 replicates in each plate
  • CV(%) = SD/meanX100
  • Intra-Assay: CV<10%
  • Inter-Assay: CV<12%
Description: This is Double-antibody Sandwich Enzyme-linked immunosorbent assay for detection of Mouse Protectin (CD59) in serum, plasma, urine and other biological fluids.

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